INT276311

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.95
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf4) DNA binding (Irf4) cytoplasm (Irf4)
Anatomy Link Frequency
plasma cell 2
Th17 cell 1
Irf4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 37 97.60 Very High Very High Very High
Arthritis 86 82.00 Quite High
Inflammation 17 71.36 Quite High
rheumatoid arthritis 56 62.56 Quite High
Inflammatory response 1 55.76 Quite High
chemokine 11 34.24 Quite Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Crohn's disease 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 90 99.32 Very High Very High Very High
Lymphatic System Cancer 280 98.04 Very High Very High Very High
Epstein-barr Virus 105 97.64 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 8 96.92 Very High Very High Very High
Mantle-cell Lymphoma 66 95.28 Very High Very High Very High
Diffuse Large B-cell Lymphoma 112 94.36 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 30 88.76 High High
Multiple Sclerosis 7 85.92 High High
Arthritis 69 82.00 Quite High
Hodgkin's Disease 50 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, as we have shown here, M2 also upregulates the expression of IRF4 [we have observed both M2-driven upregulation of IRF4 transcripts (Fig. 6C) and IRF4 protein (data not shown) in BCL-1 cells].
Gene_expression (expression) of IRF4
1) Confidence 0.64 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.06 Pain Relevance 0
As such, it is possible that M2 modulation of the levels of IRF4 may account for the apparently distinct roles of M2 in immunoglobulin isotype switching and plasma cell differentiation.
Gene_expression (modulation) of IRF4 in plasma cell
2) Confidence 0.56 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.09 Pain Relevance 0
As such, it is possible that M2 modulation of the levels of IRF4 may account for the apparently distinct roles of M2 in immunoglobulin isotype switching and plasma cell differentiation.
Gene_expression (levels) of IRF4 in plasma cell
3) Confidence 0.56 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.09 Pain Relevance 0
, MUM1/IRF4?
Gene_expression (/) of IRF4
4) Confidence 0.18 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 2.83 Pain Relevance 0
IL-1 regulated the expression of the transcription factors IRF4 and RORgammat during Th17 cell differentiation [11].
Gene_expression (expression) of IRF4 in Th17 cell
5) Confidence 0.18 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.63 Pain Relevance 0.33
The reciprocal expression pattern with IRF4 in reactive tissues was generally maintained in lymphomas with some exceptions.
Gene_expression (expression) of IRF4 associated with lymphatic system cancer
6) Confidence 0.16 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.25 Pain Relevance 0.03

General Comments

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