INT276312

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.44
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prdm1) intracellular (Prdm1) DNA binding (Prdm1)
cytoplasm (Prdm1)
Anatomy Link Frequency
plasma cell 2
Prdm1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 69.96 Quite High
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hodgkin's Disease 25 99.36 Very High Very High Very High
Epstein-barr Virus 60 88.40 High High
Diffuse Large B-cell Lymphoma 56 85.60 High High
B-cell Lymphoma 27 85.32 High High
Lymphatic System Cancer 146 83.36 Quite High
Cancer 45 82.12 Quite High
Sarcoma 4 58.00 Quite High
Sclerosis 1 43.80 Quite Low
Infection 66 6.72 Low Low
Mantle-cell Lymphoma 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the signal(s) that initiate plasma cell differentiation remain controversial, recent progress has identified several critical transcriptional regulators of plasma cell differentiation - including B lymphocyte induced maturation protein 1 (Blimp-1), interferon regulatory factor-4 (IRF-4) and XBP-1s [2],[3],[4],[5],[6].
Positive_regulation (induced) of Blimp-1 in plasma cell
1) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.34 Pain Relevance 0
untranslated region of PRDM1/Blimp-1 mRNA and high levels of miR-9 and let-7a in HL cell lines correlated with low levels of PRDM1/Blimp-1.
Positive_regulation (levels) of PRDM1 associated with hodgkin's disease
2) Confidence 0.15 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.96 Pain Relevance 0.06
Compared to M2.Stop transfected cells, there was a significant induction in the levels of transcripts encoding several plasma cell-associated factors (XBP-1s, Blimp-1, J chain and IRF-4); changes that were also observed upon LPS stimulation of the BCL-1 cell line (Fig. 6C).
Positive_regulation (induction) of Blimp-1 in plasma cell
3) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.14 Pain Relevance 0

General Comments

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