INT276316

Context Info Confidence 0.07 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.56 Pain Relevance 0

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b) nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)

Cdkn1b (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 5 5.00 corticosteroid 3 5.00 cytokine 2 5.00 Spinal cord 1 5.00 Central nervous system 1 5.00 Inflammation 1 5.00 abdominal pain 1 5.00 metalloproteinase 1 5.00 rheumatoid arthritis 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Mantle-cell Lymphoma 33 94.00 Apoptosis 5 56.88 Cancer 41 52.68 Lymphatic System Cancer 122 50.00 Diffuse Large B-cell Lymphoma 56 13.88 Severe Combined Immunodeficiency 2 12.32 Epstein-barr Virus 30 5.00 B-cell Lymphoma 27 5.00 Hodgkin's Disease 25 5.00 Follicular Lymphoma 22 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These effects are mediated by nuclear accumulation of the p27(Kip1) inhibitor induced by the downregulation of the p45(Skp2) and Cks1 proteins, which target p27(Kip1) for degradation.

Positive_regulation (accumulation) of Negative_regulation (inhibitor) of p27

1) Confidence 0.07 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.56 Pain Relevance 0

General Comments

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