INT276322

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.30
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prdm1) intracellular (Prdm1) DNA binding (Prdm1)
cytoplasm (Prdm1)
Anatomy Link Frequency
plasma cell 1
Prdm1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 64.80 Quite High
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hodgkin's Disease 25 99.50 Very High Very High Very High
Targeted Disruption 2 98.18 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 80.44 Quite High
B-cell Lymphoma 27 80.16 Quite High
Cancer 45 76.96 Quite High
Epstein-barr Virus 60 56.92 Quite High
Lymphatic System Cancer 146 56.48 Quite High
Sclerosis 1 38.64 Quite Low
Infection 66 5.00 Very Low Very Low Very Low
Mantle-cell Lymphoma 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it seems likely that under some conditions M2 activation of Vav may lead to Blimp-1 expression and entry into the plasma cell program (Fig. 6E).
Gene_expression (expression) of Blimp-1 in plasma cell
1) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.14 Pain Relevance 0
Notably, it has been shown that Vav knockout mice have very low levels of serum immunoglobulin and a severe defect in the induction of Blimp-1 expression [32].
Gene_expression (expression) of Blimp-1 associated with targeted disruption
2) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.16 Pain Relevance 0
Similar to their in vitro counterparts, the majority of HRS cells in primary HL cases showed weak or no PRDM1/Blimp-1 expression.
Neg (no) Gene_expression (expression) of PRDM1 associated with hodgkin's disease
3) Confidence 0.24 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.00 Pain Relevance 0.06

General Comments

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