INT276327

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgfr3) nucleus (Fgfr3) kinase activity (Fgfr3)
cell-cell signaling (Fgfr3) lysosome (Fgfr3) cytoplasm (Fgfr3)
Fgfr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 7 98.86 Very High Very High Very High
Lymphatic System Cancer 122 98.52 Very High Very High Very High
Targeted Disruption 14 95.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 15 90.28 High High
Congenital Anomalies 13 87.12 High High
Cancer 41 86.08 High High
Diffuse Large B-cell Lymphoma 56 75.04 Quite High
Epstein-barr Virus 30 65.56 Quite High
Aggression 1 48.52 Quite Low
Mantle-cell Lymphoma 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no compensatory up-regulation of Fgfr3 expression, and Fgfr4 mRNA could not be detected in mice of all genotypes using an RNase protection assay (Fig. 1 C).
Neg (no) Positive_regulation (up) of Gene_expression (expression) of Fgfr3
1) Confidence 0.43 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.30 Pain Relevance 0
Since recently developed drugs that target the antifibroblast growth factor receptor 3 (FGFR3) pathway are being tested in multiple myeloma in which about 15% cases carry the t(4;14) resulting in overexpression of FGFR3, Larson et al. analyzed 70 cases of malignant lymphoma.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FGFR3 associated with lymphatic system cancer and multiple myeloma
2) Confidence 0.27 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.53 Pain Relevance 0

General Comments

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