INT276343

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MDM2) intracellular (MDM2) enzyme binding (MDM2)
protein complex assembly (MDM2) protein complex (MDM2) ligase activity (MDM2)
MDM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 41 97.86 Very High Very High Very High
Mantle-cell Lymphoma 33 88.80 High High
Lymphatic System Cancer 122 79.32 Quite High
Diffuse Large B-cell Lymphoma 56 56.92 Quite High
Congenital Anomalies 3 25.28 Quite Low
Epstein-barr Virus 30 5.00 Very Low Very Low Very Low
B-cell Lymphoma 27 5.00 Very Low Very Low Very Low
Hodgkin's Disease 25 5.00 Very Low Very Low Very Low
Follicular Lymphoma 22 5.00 Very Low Very Low Very Low
Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High levels of Pim expression, as occurs in tumors, active, but not inactive, Pim-1 or Pim-2 blocks the degradation of both p53 and Mdm2 in a manner that is independent of Mdm2 phosphorylation, leading to increased p53 levels and, proportionately, p53-dependent transactivation.
Neg (independent) Regulation (independent) of Phosphorylation (phosphorylation) of Mdm2 associated with cancer
1) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.85 Pain Relevance 0

General Comments

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