INT276343

Context Info Confidence 0.14 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.85 Pain Relevance 0

nucleoplasm (MDM2) intracellular (MDM2) enzyme binding (MDM2) protein complex assembly (MDM2) protein complex (MDM2) ligase activity (MDM2)

MDM2 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 5 5.00 corticosteroid 3 5.00 cytokine 2 5.00 Spinal cord 1 5.00 Central nervous system 1 5.00 Inflammation 1 5.00 abdominal pain 1 5.00 metalloproteinase 1 5.00 rheumatoid arthritis 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Cancer 41 97.86 Mantle-cell Lymphoma 33 88.80 Lymphatic System Cancer 122 79.32 Diffuse Large B-cell Lymphoma 56 56.92 Congenital Anomalies 3 25.28 Epstein-barr Virus 30 5.00 B-cell Lymphoma 27 5.00 Hodgkin's Disease 25 5.00 Follicular Lymphoma 22 5.00 Disease 22 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

High levels of Pim expression, as occurs in tumors, active, but not inactive, Pim-1 or Pim-2 blocks the degradation of both p53 and Mdm2 in a manner that is independent of Mdm2 phosphorylation, leading to increased p53 levels and, proportionately, p53-dependent transactivation.

Neg (independent) Regulation (independent) of Phosphorylation (phosphorylation) of Mdm2 associated with cancer

1) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.85 Pain Relevance 0

General Comments

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