INT276344

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PIM1) plasma membrane (PIM1) nucleus (PIM1)
cell cycle (PIM1) transcription factor binding (PIM1) cytoplasm (PIM1)
PIM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 89.20 High High
beta blocker 4 82.32 Quite High
tricyclic antidepressant 4 76.64 Quite High
Antihistamine 1 10.80 Low Low
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 33 98.56 Very High Very High Very High
Disease 59 97.56 Very High Very High Very High
Apoptosis 7 93.38 High High
Myocardial Infarction 3 83.00 Quite High
Cancer 66 82.56 Quite High
Lymphatic System Cancer 122 66.16 Quite High
Hyperplasia 4 55.28 Quite High
Diffuse Large B-cell Lymphoma 56 43.76 Quite Low
Adenocarcinoma 1 15.04 Low Low
Congenital Anomalies 3 12.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Processes that are activated by EGFR stimulation include signal transduction pathways for PI3K-Akt (related to survival and apoptosis evasion) and Ras-Raf-MEK-MAPK (relating to proliferation).15 In addition, there is an interaction between EGFR expression and signal transducers and activators of transcription 3 (eg, STAT3), which play a role in the regulation of transcription of genes involved in cell cycle progression such as Fos, Cyclin-D, CDC25A, c-Myc and Pim1 and the upregulation of antiapoptotic genes such as BCL2.16,17
Positive_regulation (upregulation) of Pim1 associated with apoptosis
1) Confidence 0.25 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.23 Pain Relevance 0
Notably, elevated Pim-1 correlates with elevated Mdm2 in MCL.
Positive_regulation (elevated) of Pim associated with mantle-cell lymphoma
2) Confidence 0.11 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.66 Pain Relevance 0
Developed by a multidisciplinary team of Irish geriatricians, pharmacists, pharmacologists, and primary care physicians, the STOPP incorporates commonly encountered instances of PIM prescribing in older adults that include drug–drug and drug–disease interactions, drugs that adversely affect older patients at risk of falls, and duplicate drug class prescriptions (Table 4).43 Its criteria are arranged according to relevant physiological systems for ease of use, and each criterion is accompanied by a concise explanation as to why the prescription is potentially inappropriate.43
Positive_regulation (instances) of PIM associated with disease
3) Confidence 0.03 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2854054 Disease Relevance 0.18 Pain Relevance 0.17

General Comments

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