INT276346

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 33 99.64 Very High Very High Very High
Apoptosis 5 79.52 Quite High
Lymphatic System Cancer 122 50.00 Quite Low
Cancer 41 41.00 Quite Low
Severe Combined Immunodeficiency 2 34.96 Quite Low
Disease 22 12.88 Low Low
Diffuse Large B-cell Lymphoma 56 5.00 Very Low Very Low Very Low
Epstein-barr Virus 30 5.00 Very Low Very Low Very Low
B-cell Lymphoma 27 5.00 Very Low Very Low Very Low
Hodgkin's Disease 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, mTOR inhibition affected cyclin D1 proteolysis only in MCL cells in which GSK-3 is under the direct control of mTOR, suggesting that different MCL subsets could be differently responsive to mTOR inhibition.
Regulation (affected) of Protein_catabolism (proteolysis) of cyclin D1 associated with mantle-cell lymphoma
1) Confidence 0.04 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.66 Pain Relevance 0

General Comments

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