INT276356

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.07
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PRDM1) intracellular (PRDM1) cytoplasm (PRDM1)
Anatomy Link Frequency
B-lymphocyte 2
spinal 1
PRDM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 15 74.36 Quite High
cytokine 35 69.96 Quite High
Inflammation 42 50.00 Quite Low
chemokine 8 40.32 Quite Low
Demyelination 11 14.24 Low Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
Peripheral nervous system 10 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Sciatic nerve 7 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hodgkin's Disease 25 99.36 Very High Very High Very High
Disease 67 96.00 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 85.60 High High
B-cell Lymphoma 27 85.32 High High
Cancer 41 82.12 Quite High
Immunization 10 80.24 Quite High
Infection 150 79.60 Quite High
Guillain-barre Syndrome 16 78.20 Quite High
Experimental Autoimmune Neuritis 15 74.36 Quite High
Malaria 326 65.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
untranslated region of PRDM1/Blimp-1 mRNA and high levels of miR-9 and let-7a in HL cell lines correlated with low levels of PRDM1/Blimp-1.
Positive_regulation (levels) of Blimp-1 associated with hodgkin's disease
1) Confidence 0.49 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.96 Pain Relevance 0.06
B-cell and plasma cell activation is reflected by high mRNA expression levels of chB6 (Bu-1) and B lymphocyte-induced maturation protein-1 (Blimp-1) in the affected spinal ganglia [38,55].
Positive_regulation (levels) of B lymphocyte-induced maturation protein-1 in spinal
2) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2825213 Disease Relevance 0.41 Pain Relevance 0.07
Several mechanisms involved in plasma cell differentiation and survival have been described, such as B-lymphocyte-induced maturation protein 1 (Blimp1) and A proliferation inducing ligand (APRIL).
Positive_regulation (induced) of maturation protein 1 in B-lymphocyte
3) Confidence 0.35 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.35 Pain Relevance 0
Several mechanisms involved in plasma cell differentiation and survival have been described, such as B-lymphocyte-induced maturation protein 1 (Blimp1) and A proliferation inducing ligand (APRIL).
Positive_regulation (induced) of Blimp1 in B-lymphocyte
4) Confidence 0.35 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.35 Pain Relevance 0

General Comments

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