INT276358

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Context Info
Confidence 0.74
First Reported 2008
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 42
Total Number 45
Disease Relevance 38.44
Pain Relevance 7.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synovium 9
leukocytes 8
plasma 6
blood 2
joint 1
MIR150 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 275 100.00 Very High Very High Very High
rheumatoid arthritis 998 99.84 Very High Very High Very High
Osteoarthritis 300 99.66 Very High Very High Very High
Inflammation 428 98.20 Very High Very High Very High
Multiple sclerosis 24 88.48 High High
Inflammatory response 54 88.40 High High
methotrexate 12 54.24 Quite High
cINOD 27 53.12 Quite High
Bioavailability 1 22.24 Low Low
Pain 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 2727 100.00 Very High Very High Very High
Cancer 284 100.00 Very High Very High Very High
Necrosis 99 100.00 Very High Very High Very High
Rheumatoid Arthritis 1002 99.84 Very High Very High Very High
Disease 599 99.70 Very High Very High Very High
Osteoarthritis 288 99.66 Very High Very High Very High
Hyperplasia 30 99.16 Very High Very High Very High
INFLAMMATION 440 98.20 Very High Very High Very High
Aggression 29 98.00 Very High Very High Very High
Disease Progression 12 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified a ratio between the quantitative RT-PCR expression of miR-150 and a nonvariable control miR-192 that can be used to assess the severity of sepsis based on its correlation with the SOFA score.
Gene_expression (expression) of miR-150 associated with sepsis
1) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.86 Pain Relevance 0.03
Therefore, we investigated the expression of miR-150 in plasma by performing qRT-PCR on 24 sepsis (including 16 at day 1 and 8 at day 7) and 32 control samples.
Spec (investigated) Gene_expression (expression) of miR-150 in plasma associated with sepsis
2) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.64 Pain Relevance 0
In both types of analyses, we identified four miRNAs— miR-150, miR-182, miR-342-5p and miR-486 —whose expression levels differed by at least a factor of 2 between sepsis and healthy samples (p?
Gene_expression (expression) of miR-150 associated with sepsis
3) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.51 Pain Relevance 0
By using genome-wide miRNA profiling by microarray in peripheral blood leukocytes, we found that miR-150, miR-182, miR-342-5p, and miR-486 expression profiles differentiated sepsis patients from healthy controls.
Gene_expression (expression) of miR-150 in leukocytes associated with sepsis
4) Confidence 0.74 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2756627 Disease Relevance 0.86 Pain Relevance 0
We found not only that miR-150 levels are significantly different in patients and healthy controls, but also that the levels of miR-150 correlate with SOFA scores (but not with WBC).
Gene_expression (levels) of miR-150
5) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.71 Pain Relevance 0
Three of 15 miRNAs (miR-16, miR-21, and miR-150) showed a high expression level in both blood and lymph node samples.
Gene_expression (expression) of miR-150 in blood
6) Confidence 0.65 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.31 Pain Relevance 0
We found that the expression levels of miR-150 correlated with those of main immune response genes, such as TNF-alpha, IL-10, and IL-18.
Gene_expression (expression) of miR-150
7) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.74 Pain Relevance 0.13
Therefore, in addition to miR-155 [34] and miR-125 [35], miR-150 could be one of the main regulatory miRNAs of immune function, and our study unraveled the clinical significance of the miR-150 expression correlation with cytokine expression in patients with sepsis.
Gene_expression (expression) of miR-150 associated with sepsis and cytokine
8) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.80 Pain Relevance 0.13
These data suggest possible direct interactions and, more important for our clinical study, suggest possible negative correlations between the expression of cytokines and miR-150 in patient samples.
Gene_expression (expression) of miR-150 associated with cytokine
9) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 1.00 Pain Relevance 0.30
One of the important regulators is miR-150, and this is significantly abnormally expressed in both leukocytes and plasma from sepsis patients.
Gene_expression (expressed) of miR-150 in plasma associated with sepsis
10) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.78 Pain Relevance 0.09
0.01; FDR<0.08): miR-486 and miR-182 were overexpressed, while miR-150 and miR-342-5p were downregulated in sepsis patients.
Gene_expression (overexpressed) of miR-150 associated with sepsis
11) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.47 Pain Relevance 0
We found not only that miR-150 levels are significantly different in patients and healthy controls, but also that the levels of miR-150 correlate with SOFA scores (but not with WBC).
Gene_expression (levels) of miR-150
12) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.73 Pain Relevance 0
Therefore, plasma levels of miR-150 (expressed as ratio with miR-192) reproduced the variations in leukocytes, and represent a reliable indicator of early sepsis.
Gene_expression (expressed) of miR-150 in leukocytes associated with sepsis
13) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.59 Pain Relevance 0
One way to do this was to identify correlations in clinical samples between levels of miR-150 expression and that of important protein-coding genes involved in the pathogenesis of sepsis.
Gene_expression (expression) of miR-150 associated with sepsis
14) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.39 Pain Relevance 0
Therefore, plasma levels of miR-150 (expressed as ratio with miR-192) reproduced the variations in leukocytes, and represent a reliable indicator of early sepsis.
Gene_expression (reproduced) of miR-150 in leukocytes associated with sepsis
15) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.59 Pain Relevance 0
Therefore, consistently lower levels of miR-150 were found in both leukocyte and plasma samples from sepsis patients than in healthy controls, and lower expression was associated with poor clinical condition as indicated by the SOFA score.


Gene_expression (expression) of miR-150 in plasma associated with sepsis
16) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.64 Pain Relevance 0
We found that plasma levels of tumor necrosis factor alpha, interleukin-10, and interleukin-18, all genes with sequence complementarity to miR-150, were negatively correlated with the plasma levels of this miRNA.
Gene_expression (levels) of miR-150 in plasma associated with necrosis and cancer
17) Confidence 0.64 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2756627 Disease Relevance 1.08 Pain Relevance 0
Importantly, we did not find any correlation between the plasma levels of miR-150 and the number of leukocytes (expressed as white blood count, WBC) in sepsis patients (Figure S1), meaning that this downregulation is not just a biomarkers for the amount of circulating leukocytes.
Gene_expression (levels) of miR-150 in leukocytes associated with sepsis
18) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.58 Pain Relevance 0
In studying the expression of miR-150 in plasma of the sepsis patients (qRT-PCR data), we noticed a correlation between the fold-difference value and SOFA score and/or associated severity of sepsis (grades labeled as sepsis, severe sepsis, and septic shock).
Gene_expression (expression) of miR-150 in plasma associated with sepsis
19) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 0.83 Pain Relevance 0
We propose that miR-150 levels in both leukocytes and plasma correlate with the aggressiveness of sepsis and can be used as a marker of early sepsis.
Gene_expression (levels) of miR-150 in leukocytes associated with aggression and sepsis
20) Confidence 0.57 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2756627 Disease Relevance 0.90 Pain Relevance 0

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