INT276359

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MDM2) intracellular (MDM2) enzyme binding (MDM2)
protein complex assembly (MDM2) protein complex (MDM2) ligase activity (MDM2)
MDM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 10 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 82 100.00 Very High Very High Very High
Mantle-cell Lymphoma 66 86.88 High High
Lymphatic System Cancer 244 84.24 Quite High
Diffuse Large B-cell Lymphoma 112 61.84 Quite High
Congenital Anomalies 6 30.20 Quite Low
Multiple Myeloma 14 9.44 Low Low
Epstein-barr Virus 60 5.00 Very Low Very Low Very Low
B-cell Lymphoma 54 5.00 Very Low Very Low Very Low
Hodgkin's Disease 50 5.00 Very Low Very Low Very Low
Follicular Lymphoma 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High levels of Pim expression, as occurs in tumors, active, but not inactive, Pim-1 or Pim-2 blocks the degradation of both p53 and Mdm2 in a manner that is independent of Mdm2 phosphorylation, leading to increased p53 levels and, proportionately, p53-dependent transactivation.
Positive_regulation (occurs) of Protein_catabolism (degradation) of Mdm2 associated with cancer
1) Confidence 0.15 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.93 Pain Relevance 0
High levels of Pim expression, as occurs in tumors, active, but not inactive, Pim-1 or Pim-2 blocks the degradation of both p53 and Mdm2 in a manner that is independent of Mdm2 phosphorylation, leading to increased p53 levels and, proportionately, p53-dependent transactivation.
Neg (independent) Positive_regulation (independent) of Protein_catabolism (degradation) of Mdm2 associated with cancer
2) Confidence 0.15 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.86 Pain Relevance 0

General Comments

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