INT276369

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.80
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocytes 1
polymorphonuclear neutrophils 1
MIR9-1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 90.24 High High
cytokine 56 87.36 High High
Inflammatory response 8 69.64 Quite High
Inflammation 57 44.40 Quite Low
Inflammatory stimuli 2 36.28 Quite Low
Multiple sclerosis 316 5.00 Very Low Very Low Very Low
Central nervous system 55 5.00 Very Low Very Low Very Low
chemokine 11 5.00 Very Low Very Low Very Low
tolerance 10 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hodgkin's Disease 25 99.40 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 88.16 High High
B-cell Lymphoma 27 87.88 High High
Cancer 57 84.68 Quite High
Death 15 84.56 Quite High
INFLAMMATION 71 69.28 Quite High
Necrosis 4 67.48 Quite High
Lymphatic System Cancer 122 50.00 Quite Low
Sclerosis 1 46.36 Quite Low
Autoimmune Disease 92 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
untranslated region of PRDM1/Blimp-1 mRNA and high levels of miR-9 and let-7a in HL cell lines correlated with low levels of PRDM1/Blimp-1.
Positive_regulation (levels) of miR-9 associated with hodgkin's disease
1) Confidence 0.49 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.97 Pain Relevance 0.07
Involvement of miR-155 in the TLR-induced antigen presentation pathway was confirmed by a study showing that miR-155-deficient DCs are unable to induce efficient T-cell activation, with impaired antigen presentation and costimulation [137]. miR-9 is upregulated in both polymorphonuclear neutrophils and monocytes after TLR4 activation.
Positive_regulation (upregulated) of miR-9 in polymorphonuclear neutrophils
2) Confidence 0.45 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.42 Pain Relevance 0.12
Involvement of miR-155 in the TLR-induced antigen presentation pathway was confirmed by a study showing that miR-155-deficient DCs are unable to induce efficient T-cell activation, with impaired antigen presentation and costimulation [137]. miR-9 is upregulated in both polymorphonuclear neutrophils and monocytes after TLR4 activation.
Positive_regulation (upregulated) of miR-9 in monocytes
3) Confidence 0.15 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.42 Pain Relevance 0.12

General Comments

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