INT276370

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MDM2) intracellular (MDM2) enzyme binding (MDM2)
protein complex assembly (MDM2) protein complex (MDM2) ligase activity (MDM2)
MDM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 132 97.56 Very High Very High Very High
Apoptosis 10 96.12 Very High Very High Very High
Ovarian Cancer 3 95.56 Very High Very High Very High
Breast Cancer 123 94.00 High High
Mantle-cell Lymphoma 33 88.80 High High
Lymphatic System Cancer 124 78.72 Quite High
Recurrence 12 67.04 Quite High
Disease 38 62.56 Quite High
Diffuse Large B-cell Lymphoma 56 56.32 Quite High
Congenital Anomalies 3 24.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was reported that HER2 overexpression in p53 wild-type human ovarian carcinoma cell line induced apoptosis shortly after transfection, while HER2 expression was associated with proliferation in cells with mutated p53.109 It was also reported that HER2/neu induces p53 ubiquitination via Akt-mediated Mdm2 phosphorylation and inactivates p53 in Arf-deficient cells.110 Thus, both ARF and p53 are important genetic determinants in susceptibility to HER2 overexpression in breast cancer.
Phosphorylation (phosphorylation) of Mdm2 associated with breast cancer, ovarian cancer and apoptosis
1) Confidence 0.50 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.15 Pain Relevance 0
High levels of Pim expression, as occurs in tumors, active, but not inactive, Pim-1 or Pim-2 blocks the degradation of both p53 and Mdm2 in a manner that is independent of Mdm2 phosphorylation, leading to increased p53 levels and, proportionately, p53-dependent transactivation.
Phosphorylation (phosphorylation) of Mdm2 associated with cancer
2) Confidence 0.26 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.84 Pain Relevance 0

General Comments

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