INT276380

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PIM1, Trp53) nucleus (PIM1, Trp53) cell cycle (PIM1, Trp53)
transcription factor binding (PIM1, Trp53) nucleoplasm (Trp53) mitochondrion (Trp53)
PIM1 (Homo sapiens)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 33 98.12 Very High Very High Very High
Cancer 41 78.64 Quite High
Lymphatic System Cancer 122 62.24 Quite High
Diffuse Large B-cell Lymphoma 56 39.84 Quite Low
Congenital Anomalies 3 8.20 Low Low
Epstein-barr Virus 30 5.00 Very Low Very Low Very Low
B-cell Lymphoma 27 5.00 Very Low Very Low Very Low
Hodgkin's Disease 25 5.00 Very Low Very Low Very Low
Follicular Lymphoma 22 5.00 Very Low Very Low Very Low
Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are consistent with the idea that Pim normally interacts with the p53 pathway but, when expressed at pathological levels, like in MCL, behaves as a classic dominant oncogene that stimulates a protective response through the induction of the p53 pathway [11].
Pim Binding (interacts) of p53 associated with mantle-cell lymphoma
1) Confidence 0.01 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.66 Pain Relevance 0

General Comments

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