INT276381

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) cell adhesion (CD44) proteinaceous extracellular matrix (Timp1)
plasma membrane (CD44)
Anatomy Link Frequency
centrocyte 1
Timp1 (Mus musculus)
CD44 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1 86.60 High High
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epstein-barr Virus 30 95.20 Very High Very High Very High
B-cell Lymphoma 27 91.96 High High
Colon Cancer 1 85.04 High High
Diffuse Large B-cell Lymphoma 56 76.16 Quite High
Lymphatic System Cancer 122 72.80 Quite High
Hodgkin's Disease 25 38.04 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 15 33.04 Quite Low
Aggression 1 24.64 Low Low
Cancer 41 19.68 Low Low
Mantle-cell Lymphoma 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kim et al. show that TIMP1 upregulates cell surface CD44 (standard and variants 3 and 7–10) and induces the activity and nuclear localization of SHP1 in an Epstein–Barr virus (EBV)-negative Burkitt lymphoma (BL) cell line, the neoplastic counterpart of GC centroblasts, suggesting that TIMP1 functions as a differentiating and survival factor of GC B cells by modulating CD44 and SHP1 in the late centrocyte/post-GC stage [6].
TIMP1 Positive_regulation (upregulates) of CD44 in centrocyte associated with epstein-barr virus
1) Confidence 0.07 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.72 Pain Relevance 0.04

General Comments

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