INT276388

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Il22 (Mus musculus)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 56.48 Quite High
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Large Cell Lymphoma 20 97.28 Very High Very High Very High
Syndrome 6 94.08 High High
Malignant Neoplastic Disease 8 87.04 High High
Cancer 41 78.08 Quite High
T-cell Lymphoma 21 62.80 Quite High
Apoptosis 5 60.32 Quite High
Lymphatic System Cancer 122 50.00 Quite Low
Diffuse Large B-cell Lymphoma 56 5.00 Very Low Very Low Very Low
Mantle-cell Lymphoma 33 5.00 Very Low Very Low Very Low
Epstein-barr Virus 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nucleophosmin (NPM)-ALK, the characteristic fusion gene oncoprotein expressed in ALK(+)ALCL, directly contributes to the aberrant expression of IL-22R1, as transfection of NPM-ALK in Jurkat cells induced IL-22R1 expression and IL-22-mediated STAT3 activation [18].
IL-22-mediated Positive_regulation (activation) of STAT3 associated with anaplastic large cell lymphoma
1) Confidence 0.03 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.30 Pain Relevance 0.03

General Comments

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