INT27639

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.97
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C9orf3) cytoplasm (C9orf3)
C9orf3 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 56 96.64 Very High Very High Very High
palliative 1 90.72 High High
Angina 2 88.64 High High
Inflammatory marker 2 86.56 High High
spinal inflammation 4 50.00 Quite Low
Inflammation 11 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 49 100.00 Very High Very High Very High
Hypercholesterolemia 2 100.00 Very High Very High Very High
Hyperlipidemia 2 99.52 Very High Very High Very High
Congenital Anomalies 3 98.86 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

1 97.42 Very High Very High Very High
Rheumatoid Arthritis 56 96.64 Very High Very High Very High
Cardiovascular Disease 4 96.00 Very High Very High Very High
Disease 14 93.36 High High
Hyperlipoproteinemia Type Ii 5 88.92 High High
Cv General 3 Under Development 2 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, ERA patients exhibited a mild dyslipidemia characterized by an increase in the serum levels of total cholesterol, LDL-cholesterol, triglycerides and Apo B as well as by a decrease in the serum levels of HDL-cholesterol and Apo A-I compared with controls.
Negative_regulation (decrease) of Gene_expression (levels) of Apo associated with rheumatoid arthritis and disorder of lipid metabolism
1) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.42 Pain Relevance 0.30
The main effect of the operation is to lower the LDL apolipoprotein (apo) B-100 production rate, but there is little effect on the fractional rate of clearance of this apolipoprotein.
Negative_regulation (lower) of Gene_expression (production) of apo associated with disorder of lipid metabolism
2) Confidence 0.42 Published 1989 Journal Arteriosclerosis Section Abstract Doc Link 2643427 Disease Relevance 0.71 Pain Relevance 0.09
The most frequent lipid abnormalities found were: hypertriglyceridemia; hypercholesterolemia; decreased HDL levels; elevated cholesterol/HDL and apoproteins (Apo B/A-1); and elevated lipoprotein [Lp(a)] levels.
Negative_regulation (decreased) of Gene_expression (levels) of Apo associated with congenital anomalies, hyperlipidemia, disorder of lipid metabolism and hypercholesterolemia
3) Confidence 0.41 Published 1993 Journal Perit Dial Int Section Abstract Doc Link 8399630 Disease Relevance 1.48 Pain Relevance 0.09
This resulted in a better total cholesterol:HDL-c ratio (from 3.9 to 3.7) (although the difference was not statistically significant), and an improved Apo B:Apo A-I ratio, which decreased by 7.5% over time (P=0.008).
Negative_regulation (decreased) of Gene_expression (ratio) of Apo
4) Confidence 0.41 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19404933 Disease Relevance 0.26 Pain Relevance 0

General Comments

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