INT276390

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
blood cells 3
CD40 (Homo sapiens)
Pdcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 4 99.52 Very High Very High Very High
B-cell Lymphoma 27 95.40 Very High Very High Very High
Follicular Lymphoma 22 92.08 High High
Epstein-barr Virus 30 90.32 High High
Lymphatic System Cancer 122 89.88 High High
Mantle-cell Lymphoma 33 88.64 High High
Hodgkin's Disease 25 46.00 Quite Low
Death 1 35.24 Quite Low
Diffuse Large B-cell Lymphoma 56 5.00 Very Low Very Low Very Low
Cancer 41 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flow cytometry showed that blood cells from chronic lymphocytic leukemia (B-CLL) also displayed PD-1 expression, which could be increased by CD40 stimulation.
Positive_regulation (stimulation) of CD40 in blood cells Positive_regulation (increased) of Gene_expression (expression) of PD-1 in blood cells associated with chronic lymphoid leukemia
1) Confidence 0.01 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.06 Pain Relevance 0

General Comments

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