INT276393

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CIB1) cell adhesion (CIB1) endoplasmic reticulum (CIB1)
plasma membrane (CIB1) nucleus (CIB1) kinase activity (Skp2)
Skp2 (Mus musculus)
CIB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 33 90.92 High High
Apoptosis 5 63.92 Quite High
Lymphatic System Cancer 122 50.00 Quite Low
Cancer 41 49.60 Quite Low
Severe Combined Immunodeficiency 2 19.36 Low Low
Diffuse Large B-cell Lymphoma 56 10.80 Low Low
Epstein-barr Virus 30 5.00 Very Low Very Low Very Low
B-cell Lymphoma 27 5.00 Very Low Very Low Very Low
Hodgkin's Disease 25 5.00 Very Low Very Low Very Low
Follicular Lymphoma 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects are mediated by nuclear accumulation of the p27(Kip1) inhibitor induced by the downregulation of the p45(Skp2) and Cks1 proteins, which target p27(Kip1) for degradation.
p45 Regulation (target) of Kip1
1) Confidence 0.00 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.57 Pain Relevance 0

General Comments

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