INT276401

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.62
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MALT1) peptidase activity (MALT1) nucleolus (MALT1)
nucleus (MALT1) protein complex (MALT1) cytoplasm (MALT1)
Anatomy Link Frequency
MALT 1
central nervous system 1
MALT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 52 98.60 Very High Very High Very High
Spinal cord 8 93.72 High High
imagery 8 82.92 Quite High
Inflammation 8 81.44 Quite High
headache 8 30.12 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 4 100.00 Very High Very High Very High
Lymphatic System Cancer 184 99.44 Very High Very High Very High
Epstein-barr Virus 20 97.88 Very High Very High Very High
Hodgkin's Disease 16 96.16 Very High Very High Very High
Cancer 52 93.76 High High
Disease 12 92.04 High High
Generaliased Trisomy 8 85.60 High High
INFLAMMATION 8 81.44 Quite High
Chromosome Aberrations 8 78.88 Quite High
Macroglobulinemia 4 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our case suggests that MALT1 translocation play a pathogenetic role in some PCNS MALT lymphoma similar to the other extranodal lymphoma.
Localization (translocation) of MALT1 in MALT associated with lymphatic system cancer
1) Confidence 0.60 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 1.02 Pain Relevance 0
The FISH study for MALT1 translocations showed a rearrangement of the MALT1 region at 18q21 in 30% of the interphase cells.
Localization (translocations) of MALT1
2) Confidence 0.60 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.88 Pain Relevance 0
portion of API2, an inhibitor of apoptosis located at 11q21 leading to production of API2-MALT1 fusion transcript [22].
Localization (portion) of MALT1 associated with apoptosis
3) Confidence 0.56 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 1.17 Pain Relevance 0.04
Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literature

Primary central nervous system lymphoma (PCNSL) is an extranodal non-Hodgkin lymphoma involving brain, intraocular structures and spinal cord, without evidence of systemic disease.

Localization (translocation) of MALT1 in central nervous system associated with lymphatic system cancer, hodgkin's disease, central nervous system, disease and spinal cord
4) Confidence 0.52 Published 2008 Journal J Hematop Section Title Doc Link PMC2713483 Disease Relevance 0.55 Pain Relevance 0.14

General Comments

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