INT276408

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
puncture 2
Imraq3 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 10 98.80 Very High Very High Very High
Lasting pain 2 95.96 Very High Very High Very High
Spinal cord 31 88.76 High High
medulla 1 83.16 Quite High
dorsal rhizotomy 3 55.28 Quite High
Dorsal horn 10 46.00 Quite Low
Calcitonin gene-related peptide 18 5.00 Very Low Very Low Very Low
substance P 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 23 99.96 Very High Very High Very High
Lumbar Puncture Related Headaches 11 97.56 Very High Very High Very High
Pain 11 95.96 Very High Very High Very High
Retinal Diseases 8 72.96 Quite High
Disease 8 68.08 Quite High
Ocular Toxicity (including Many Sub-types) 3 66.44 Quite High
Skin Cancer 1 65.52 Quite High
Muscular Dystrophy 11 64.48 Quite High
Retinoschisis 1 64.28 Quite High
Night Blindness 1 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To explore therapeutic gene delivery to the OPL we delivered AAV-9.CMV.?
Positive_regulation (delivered) of Gene_expression (delivered) of AAV-9 associated with cytomegalovirus infection
1) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.81 Pain Relevance 0
In this study we have compared expression patterns of AAV serotype 5 (AAV5)- and AAV serotype 8 (AAV8)-mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture.


Positive_regulation (transfer) of Gene_expression (expression) of AAV5 in puncture associated with lumbar puncture related headaches and intrathecal
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2900238 Disease Relevance 0.45 Pain Relevance 0.49

General Comments

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