INT276410

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 6.31
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
retina 2
neurons 2
puncture 2
blood 1
eyes 1
Imraq3 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 72 98.60 Very High Very High Very High
Dorsal horn 40 98.56 Very High Very High Very High
intrathecal 40 96.76 Very High Very High Very High
Lasting pain 8 95.96 Very High Very High Very High
cytokine 42 94.52 High High
Spinal cord 124 94.40 High High
substantia gelatinosa 8 89.92 High High
medulla 4 83.16 Quite High
Pain 28 70.60 Quite High
Intracerebroventricular 8 63.00 Quite High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 161 99.96 Very High Very High Very High
Cancer 128 96.36 Very High Very High Very High
Muscular Dystrophy 77 96.00 Very High Very High Very High
Pain 44 95.96 Very High Very High Very High
Lumbar Puncture Related Headaches 44 95.52 Very High Very High Very High
Retinal Diseases 56 94.72 High High
Disease 56 93.44 High High
Ocular Toxicity (including Many Sub-types) 21 90.28 High High
Skin Cancer 7 89.36 High High
Retinoschisis 7 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant AAV-9 production
Gene_expression (production) of AAV-9
1) Confidence 0.11 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.07 Pain Relevance 0
To explore therapeutic gene delivery to the OPL we delivered AAV-9.CMV.?
Gene_expression (delivered) of AAV-9 associated with cytomegalovirus infection
2) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.81 Pain Relevance 0
To determine whether AAV-9 can be used to deliver a therapeutic gene to the OPL, we performed subretinal injection in mdx3cv mice using AAV-9.CMV.?
Gene_expression (using) of AAV-9 associated with cytomegalovirus infection
3) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.85 Pain Relevance 0
Consistent with recent publications from other investigators, we observed robust AAV-9 transduction in the outer retina (RPE and ONL), inner retina (Müller cells), and RGC layers [12,13].
Gene_expression (transduction) of AAV-9 in retina
4) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 1.01 Pain Relevance 0
Consistent with our findings in reporter AAV vector-infected normal eyes, we observed efficient OPL transduction in the eyes of AAV-9.CMV.?
Gene_expression (transduction) of AAV-9 in eyes associated with cytomegalovirus infection
5) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.84 Pain Relevance 0
In this study we examined AAV-9 transduction in young, adult, and old mice.
Spec (examined) Gene_expression (transduction) of AAV-9
6) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 1.06 Pain Relevance 0
Interestingly the OPs, highly sensitive functional indicators of the inner retina [39], were reduced following AAV-9 injection.
Gene_expression (injection) of AAV-9 in retina
7) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.21 Pain Relevance 0
Unlike our previous study in which ectopic expression of rAAV-hTERTC27 in nude mice significantly up-regulated the IL-17 mRNA level [27] in xenografted tumor tissue, administration of rAAV-/rAdv-hTERTC27 viral cocktail in C57BL/6 mice showed a little increase of IL-17 cytokine level in blood in this study.
Gene_expression (expression) of rAAV in blood associated with cancer and cytokine
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 0.25 Pain Relevance 0.24
Production of recombinant adenovirus (rAdv) and adeno-associated virus (rAAV)
Gene_expression (Production) of rAAV
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 0.27 Pain Relevance 0
Since the population of CGRP neurons is heterogeneous, this observation may indicate differential expression of receptors for AAV5 and AAV8 within the different subsets of CGRP-positive neurons.
Gene_expression (expression) of AAV5 in neurons associated with calcitonin gene-related peptide
10) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2900238 Disease Relevance 0.07 Pain Relevance 0.43
In this study we have compared expression patterns of AAV serotype 5 (AAV5)- and AAV serotype 8 (AAV8)-mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture.


Gene_expression (expression) of AAV5 in puncture associated with lumbar puncture related headaches and intrathecal
11) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2900238 Disease Relevance 0.44 Pain Relevance 0.46
In this study we have compared expression patterns of AAV serotype 5 (AAV5)- and AAV serotype 8 (AAV8)-mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture.


Gene_expression (expression) of AAV serotype 5 in puncture associated with lumbar puncture related headaches and intrathecal
12) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2900238 Disease Relevance 0.44 Pain Relevance 0.46
At cervical, lumbar and sacral level, GFP labeled fibers were seen predominantly in deeper laminae of dorsal horn and in the dorsal columns, in agreement with the observation that both AAV5 and AAV8 preferentially transduce larger diameter DRG neurons.
Gene_expression (transduce) of AAV5 in neurons associated with dorsal horn
13) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2900238 Disease Relevance 0 Pain Relevance 0.29

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