INT276413

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 0.81
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctbp2) oxidoreductase activity (Ctbp2) nucleus (Ctbp2)
Anatomy Link Frequency
pineal gland 6
mammary glands 2
retina 1
synaptic ribbon 1
Ctbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 21 89.04 High High
cva 2 41.56 Quite Low
ketamine 4 32.56 Quite Low
Glutamate 24 5.00 Very Low Very Low Very Low
Neurotransmitter 16 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
antidepressant 9 5.00 Very Low Very Low Very Low
noradrenaline 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 46 99.88 Very High Very High Very High
Targeted Disruption 3 88.80 High High
Retinal Diseases 16 83.20 Quite High
Muscular Dystrophy 22 66.48 Quite High
Disease 16 63.92 Quite High
Muscle Disease 2 58.48 Quite High
Ganglion Cysts 4 54.88 Quite High
Retina Disease 4 42.96 Quite Low
Respiratory Syncytial Virus 26 41.28 Quite Low
Cataract 2 40.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further confirm OPL transduction, we stained AAV-9.CMV.eGFP-infected eyes with CtBP2, a marker for the photoreceptor synaptic ribbon (Figure 2 E,G,H).
Gene_expression (infected) of CtBP2 in synaptic ribbon associated with cytomegalovirus infection
1) Confidence 0.46 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.64 Pain Relevance 0
For eGFP and CtBP2 detection, the eyeballs were first fixed in 4% paraformaldehyde and phosphate-buffer saline (PBS,, 0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4) then cryoprotected in 30% sucrose/PBS overnight.
Gene_expression (detection) of CtBP2
2) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0 Pain Relevance 0
We assessed the expression of RIBEYE in the pineal organ on immunoblots with the B-domain-specific RIBEYE antibody (Fig. 1).
Gene_expression (expression) of RIBEYE in pineal organ
3) Confidence 0.35 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2757586 Disease Relevance 0 Pain Relevance 0
Fig. 1Western blot analysis of RIBEYE expression in rat retina and pineal organ.
Gene_expression (expression) of RIBEYE in pineal organ
4) Confidence 0.35 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2757586 Disease Relevance 0 Pain Relevance 0
m

RIBEYE B/CtBP2 antibodies (Figs. 3a,b, 4a–f, 6), but not RIBEYE A antibodies (Figs. 3c,d, 4g,h), also stained the cell nuclei in the pineal gland.

Gene_expression (antibodies) of RIBEYE in pineal gland
5) Confidence 0.35 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2757586 Disease Relevance 0 Pain Relevance 0
The typical RIBEYE B/CtBP2 labeling of the SRs and nuclei (N) is stronger compared with the CtBP1 labeling (nuclei are indicated by white dots in c, d).
Gene_expression (labeling) of RIBEYE B
6) Confidence 0.35 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2757586 Disease Relevance 0 Pain Relevance 0
m

RIBEYE B/CtBP2 antibodies (Figs. 3a,b, 4a–f, 6), but not RIBEYE A antibodies (Figs. 3c,d, 4g,h), also stained the cell nuclei in the pineal gland.

Gene_expression (antibodies) of RIBEYE B in pineal gland
7) Confidence 0.35 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2757586 Disease Relevance 0 Pain Relevance 0
Staining for RIBEYE and CtBP2 in rat pineal gland
Gene_expression (Staining) of RIBEYE in pineal gland
8) Confidence 0.31 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2757586 Disease Relevance 0 Pain Relevance 0
In the rat pineal gland, the antibodies against CtBP1, Bassoon, Piccolo, Munc13–1, and KIF3A produced a strong punctuate or rod-like staining associated with RIBEYE.
Spec (like) Gene_expression (produced) of RIBEYE in pineal gland
9) Confidence 0.27 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2757586 Disease Relevance 0 Pain Relevance 0
Fig. 1Western blot analysis of RIBEYE expression in rat retina and pineal organ.
Gene_expression (expression) of RIBEYE in retina
10) Confidence 0.12 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2757586 Disease Relevance 0 Pain Relevance 0
These datasets included the GEO expression profile, GSE7407, in which gene expression in heart tissue with cardiac specific over-expression of Sirt1 was examined [13], the GEO expression profile, GSE8191, in which the gene expression profile of mammary glands from pregnant mice was compared to that of mammary glands from lactating mice [14], and the GEO expression profile, GSE2259, in which gene expression in testis from sertoli cell-selective androgen receptor knockout mice was examined [15].
Spec (examined) Gene_expression (expression) of GEO in mammary glands associated with targeted disruption
11) Confidence 0.01 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2949890 Disease Relevance 0.09 Pain Relevance 0
These datasets included the GEO expression profile, GSE7407, in which gene expression in heart tissue with cardiac specific over-expression of Sirt1 was examined [13], the GEO expression profile, GSE8191, in which the gene expression profile of mammary glands from pregnant mice was compared to that of mammary glands from lactating mice [14], and the GEO expression profile, GSE2259, in which gene expression in testis from sertoli cell-selective androgen receptor knockout mice was examined [15].
Spec (examined) Gene_expression (expression) of GEO in mammary glands associated with targeted disruption
12) Confidence 0.01 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2949890 Disease Relevance 0.08 Pain Relevance 0
For three GEO expression profiles, the results of the analysis are described in detail (Table 1).
Gene_expression (expression) of GEO
13) Confidence 0.01 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2949890 Disease Relevance 0 Pain Relevance 0.09

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