INT27642

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 10
Total Number 14
Disease Relevance 2.55
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
MBH 4
P19 2
blood 2
gonadal 2
Leydig cells 2
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Acupuncture 9 100.00 Very High Very High Very High
Intracerebroventricular 2 100.00 Very High Very High Very High
dexamethasone 8 99.92 Very High Very High Very High
analgesia 3 99.76 Very High Very High Very High
Opioid 6 98.52 Very High Very High Very High
Central grey 5 98.52 Very High Very High Very High
cINOD 4 96.08 Very High Very High Very High
Intractable pain 2 94.72 High High
fluoxetine 2 94.72 High High
Analgesic 16 91.36 High High
Disease Link Frequency Relevance Heat
Brain Injury 75 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 15 99.64 Very High Very High Very High
Embryonal Carcinoma 1 99.40 Very High Very High Very High
INFLAMMATION 4 95.52 Very High Very High Very High
Intractable Pain 2 94.72 High High
Injury 29 93.64 High High
Osteoporosis 1 93.28 High High
Urological Neuroanatomy 5 93.20 High High
Cardiovascular Disease 1 92.60 High High
Galactorrhea 2 90.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostaglandins have been shown to be involved in the regulation of renal function as well as erythropoietin (Ep) production.
Regulation (regulation) of Gene_expression (production) of Ep
1) Confidence 0.44 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.10 Pain Relevance 0.35
In conclusion, repeated administration of KT showed no impairment of Ep production and release in response to reduced hematocrit, suggesting that in this instance, prostaglandin inhibition plays a minimal role in Ep production or release.
Regulation (impairment) of Gene_expression (production) of Ep
2) Confidence 0.44 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.08 Pain Relevance 0.07
The opioid peptide beta-endorphin (beta-EP), and the neurosteroid allopregnanolone are considered markers of neuroendocrine function and their synthesis and action is regulated by gonadal steroids.
Regulation (regulated) of Gene_expression (synthesis) of beta-EP in gonadal
3) Confidence 0.41 Published 2002 Journal Maturitas Section Abstract Doc Link 12443836 Disease Relevance 0.28 Pain Relevance 0.10
A similar second experiment was designed to determine if blood loss was the cause of altered Ep production.
Regulation (altered) of Gene_expression (production) of Ep in blood associated with pressure volume 2 under development
4) Confidence 0.26 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.16 Pain Relevance 0.26
In conclusion, repeated administration of KT showed no impairment of Ep production and release in response to reduced hematocrit, suggesting that in this instance, prostaglandin inhibition plays a minimal role in Ep production or release.
Regulation (role) of Gene_expression (production) of Ep
5) Confidence 0.26 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.08 Pain Relevance 0.07
In our study, the mean warm ischemic time was not significantly different between the HALDN and ODN groups.
Neg (not) Regulation (different) of Gene_expression (groups) of ODN
6) Confidence 0.24 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2858855 Disease Relevance 0.06 Pain Relevance 0
Our previous study investigated the alteration of expression patterns of mGluRs after DBI alone.
Spec (investigated) Regulation (alteration) of Gene_expression (expression) of DBI associated with brain injury
7) Confidence 0.18 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.87 Pain Relevance 0.24
The results indicate that 5-HT may modulate the levels of brain beta-Ep.
Regulation (modulate) of Gene_expression (levels) of beta-Ep in brain
8) Confidence 0.14 Published 1986 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3010328 Disease Relevance 0.32 Pain Relevance 0.42
For this purpose, we established a genetically modified embryonal carcinoma cell line (P19) in which the expression of beta-endorphin (beta-EP) could be controlled by the addition of dexamethasone.
Regulation (controlled) of Gene_expression (expression) of beta-EP in P19 associated with embryonal carcinoma and dexamethasone
9) Confidence 0.11 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 11031086 Disease Relevance 0.27 Pain Relevance 0.58
Fetal Leydig cells were maintained in culture for 5 days in medium with 1 microgram ovine LH added every third day in the presence or absence of inhibitors of cholesterol (aminoglutethimide) or pregnenolone metabolism (cyanoketone and spironolactone), or known regulators of beta EP production [dexamethasone (DEX)].
Regulation (regulators) of Gene_expression (production) of EP in Leydig cells associated with dexamethasone
10) Confidence 0.07 Published 1988 Journal Endocrinology Section Abstract Doc Link 2962854 Disease Relevance 0 Pain Relevance 0.17
The effect of acupuncture on the concentrations of arginine vasopressin (AVP), oxytocin (OXT), leucine-enkephaline (L-Ek), beta-endorphin (beta-Ep) and dynorphinA(1-13) (DynA(1-13)) was investigated in rat PVH.
Spec (investigated) Regulation (effect) of Spec (investigated) Gene_expression (concentrations) of beta-Ep in PVH associated with acupuncture
11) Confidence 0.05 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16459202 Disease Relevance 0.08 Pain Relevance 0.61
These include: (1) the detection of significant beta-endorphin (beta-EP) production by rat Leydig cells (Lc) in cultures; (2) the hormonal regulation of Lc beta-EP production by positive (gonadotropins) and negative (steroids, glucocorticoids, GnRH) factors; (3) the presence of opioid binding sites (Kd in the nanomolar range) in tubular homogenates and Sertoli cells (Sc) in culture of adult and immature rat testes; (4) the inhibition of basal and FSH-stimulated ABP production by Sc in culture when chronically exposed to beta-EP treatment; (5) the detection of high levels of beta-EP and met-enkephalin in human semen with values 6-12 times higher than in plasma; (6) the evidence for inhibitory functions of seminal opioids on sperm motility, vas deferens muscle contraction and partner immune system.
Regulation (regulation) of Gene_expression (production) of beta-EP in Sertoli cells associated with sperm disorder, enkephalin and opioid
12) Confidence 0.05 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2643737 Disease Relevance 0.08 Pain Relevance 0.51
In this study we have therefore examined the effects of chronic peripheral and intracerebroventricular (i.c.v.) infusion of ovine PRL on POMC gene expression and beta-EP levels in the medial basal hypothalamus (MBH) of castrated male and female rats.
Spec (examined) Regulation (effects) of Gene_expression (expression) of beta-EP in MBH associated with intracerebroventricular
13) Confidence 0.04 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9041359 Disease Relevance 0.09 Pain Relevance 0.14
In this study we have therefore examined the effects of chronic peripheral and intracerebroventricular (i.c.v.) infusion of ovine PRL on POMC gene expression and beta-EP levels in the medial basal hypothalamus (MBH) of castrated male and female rats.
Spec (examined) Regulation (effects) of Gene_expression (levels) of beta-EP in MBH associated with intracerebroventricular
14) Confidence 0.04 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9041359 Disease Relevance 0.09 Pain Relevance 0.14

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