INT27644

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Context Info
Confidence 0.65
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 6.97
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BRD2)
Anatomy Link Frequency
liver 3
pituitary 2
gonadotroph 2
embryos 1
blood 1
BRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 183 99.24 Very High Very High Very High
antagonist 128 97.48 Very High Very High Very High
Opioid 3 96.68 Very High Very High Very High
Enkephalin 1 95.32 Very High Very High Very High
anesthesia 4 87.92 High High
headache 42 84.80 Quite High
imagery 20 70.56 Quite High
Morphine 1 66.40 Quite High
Central nervous system 3 66.16 Quite High
Pain 32 64.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 118 99.88 Very High Very High Very High
Reprotox - General 1 65 99.64 Very High Very High Very High
Hemorrhage 5 99.64 Very High Very High Very High
Diabetes Insipidus 6 99.40 Very High Very High Very High
Ovarian Hyperstimulation Syndrome 132 99.38 Very High Very High Very High
Adenoma 95 99.20 Very High Very High Very High
Galactorrhea 23 97.20 Very High Very High Very High
Pituitary Cancer 42 96.36 Very High Very High Very High
Body Weight 8 95.84 Very High Very High Very High
Sperm Disorder 1 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pituitary function test after the operation showed that seven patients had GH deficiency, eight had TSH deficiency, nine had ACTH deficiency, six had LH/FSH deficiency, and nine had diabetes insipidus.
Gene_expression (deficiency) of FSH in pituitary associated with diabetes insipidus
1) Confidence 0.65 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3004488 Disease Relevance 1.23 Pain Relevance 0.17
TSH deficiency was present in five patients, ACTH deficiency in nine patients, and LH-FSH deficiency in eight patients (see Table 1).


Gene_expression (deficiency) of FSH
2) Confidence 0.65 Published 2009 Journal Pituitary Section Body Doc Link PMC2764055 Disease Relevance 0.18 Pain Relevance 0
Very occasionally, some human pituitary tumors demonstrate their functional differentiation toward the production of hormones belonging to different cell lineages, i.e., ACTHomas with GH production, GHomas with ACTH production, FSHomas with ACTH production and so on.
Gene_expression (production) of FSH in pituitary associated with pituitary cancer
3) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 0.73 Pain Relevance 0
In a group of cycling female Rhesus monkeys exposed to ovulation induction with hFSH and hFSH + hLH in the absence or presence of the 3?
Gene_expression (exposed) of FSH
4) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.19 Pain Relevance 0
Furthermore, it has been demonstrated that co-administration of rhLH and rhFSH (follitropin ?)
Gene_expression (administration) of FSH
5) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.06 Pain Relevance 0
These include: (1) the detection of significant beta-endorphin (beta-EP) production by rat Leydig cells (Lc) in cultures; (2) the hormonal regulation of Lc beta-EP production by positive (gonadotropins) and negative (steroids, glucocorticoids, GnRH) factors; (3) the presence of opioid binding sites (Kd in the nanomolar range) in tubular homogenates and Sertoli cells (Sc) in culture of adult and immature rat testes; (4) the inhibition of basal and FSH-stimulated ABP production by Sc in culture when chronically exposed to beta-EP treatment; (5) the detection of high levels of beta-EP and met-enkephalin in human semen with values 6-12 times higher than in plasma; (6) the evidence for inhibitory functions of seminal opioids on sperm motility, vas deferens muscle contraction and partner immune system.
Gene_expression (production) of FSH in Sertoli cells associated with sperm disorder, enkephalin and opioid
6) Confidence 0.58 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2643737 Disease Relevance 0.09 Pain Relevance 0.51
In all patients baseline blood samples were obtained before operation (2–3 days after the commencement of spontaneous or progesterone induced menstrual bleeding) to assess serum levels of LH, FSH, PRL, DHEAS and T.
Gene_expression (levels) of FSH in blood associated with hemorrhage
7) Confidence 0.58 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1188073 Disease Relevance 0.43 Pain Relevance 0.09
Feasibility and acceptability of the NAT: PD-C
Gene_expression (Feasibility) of NAT
8) Confidence 0.34 Published 2010 Journal BMC Palliat Care Section Body Doc Link PMC2820447 Disease Relevance 0.12 Pain Relevance 0.03
Human UGT, SULT, NAT, and GST mRNA were expressed in the liver of the chimeric mice, and UGT2B7, SULT1E1, SULT2A1, and GSTA1 proteins could be detected.
Gene_expression (expressed) of NAT in liver
9) Confidence 0.10 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15932951 Disease Relevance 0 Pain Relevance 0.07
Using the same three alkylanilines listed in Table I, we assessed DNA binding of radioisotope catalyzed by human liver S9 in the absence and presence of cofactors that promote N-acetyltransferase (NAT), sulfotransferase and glucuronyl transferase activities.
Gene_expression (promote) of NAT in liver
10) Confidence 0.06 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0 Pain Relevance 0
Transfection of UV5 cells with mouse P450 1A2 complementary DNA established the UV5P3 line (72), which was subsequently transfected with human aryl sulfotransferase (HAST1) or NAT2 from a human liver complementary DNA library (70,73), producing CHO cells that are NER deficient (or proficient) and express mouse P4501A2 plus human aryl sulfotransferase or NAT genes.
Gene_expression (express) of NAT in liver
11) Confidence 0.05 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0 Pain Relevance 0.03
In a systematic review where trials using GnRH agonists and antagonist cycles were pooled, live birth rates and clinical pregnancy rates were similar regardless of whetherrLH was co-administrated with rFSH or not.108
Gene_expression (with) of rFSH associated with antagonist and agonist
12) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.21 Pain Relevance 0.18
Results of a recent Cochrane review do not confirm an increase in live birth rates associated with the addition of rLH to rFSH in GnRH agonist downregulated IVF cycles compared to rFSH only stimulated cycles (two trials: OR 1.51, 95% CI 0.79 to 2.87).79
Gene_expression (cycles) of rFSH associated with agonist
13) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.12 Pain Relevance 0.20
An RCT which included 84 participants found no significant difference in pregnancy rate between poor responders treated with either rFSH alone or rLH and FSH in an GnRH agonist flare up protocol.107
Gene_expression (alone) of rFSH associated with agonist
14) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.30 Pain Relevance 0.19
However, there were only three trials with a total of 234 participants and the authors concluded that more studies were needed to confirm this finding.133 The two RCTs included in this meta-analysis, where follitropin alpha was administered, showed no significant difference in pregnancy rates between groups which received rFSH injections compared to those which received placebo or no treatment.136,137 Treatment of azospermic men with rFSH for 10 months prior to ICSI may lead to detection of sperms in the ejaculate and spare these men surgical sperm retrieval procedures.138 As age of the female partner is considered the single most important factor in predicting success of other interventions such as ICSI, the benefit of this relatively long period of treatment may need to be weighed up against the expected advancement in maternal age, especially in women above 35.
Gene_expression (injections) of rFSH in sperm
15) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.25 Pain Relevance 0
Neither systematic review has shown any differences in rates of multiple pregnancy rates, ovarian hyperstimulation or miscarriage.77,78 Unlike Coomarasamy and his colleagues, Al-Inany et al reported a significant reduction in dose and duration of stimulation and available embryos in the rFSH group.77
Gene_expression (group.77) of rFSH in embryos associated with reprotox - general 1
16) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.10 Pain Relevance 0
There were no differences in other IVF outcomes such as OHSS, number of oocytes retrieved, amount of rFSH used, serum estradiol level on the day of HCG administration and miscarriage rate.79
Gene_expression (amount) of rFSH in oocytes associated with ovarian hyperstimulation syndrome and reprotox - general 1
17) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.36 Pain Relevance 0.23
There was no difference in the risk of early miscarriage between women on rFSH who were co-treated with rLH (eight trials: OR 0.59, 95% CI 0.35 to 1.02) compared to women who were treated with rFSH alone.79 However, after exclusion of a single trial that used a flare up GnRH protocol, a trend towards reduced miscarriage rates (of borderline significance) was found in women co-treated rLH (seven trials: OR 0.57, 95% CI 0.33 to 1.00).
Gene_expression (who) of rFSH associated with reprotox - general 1
18) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.25 Pain Relevance 0.13
The use of uHMG for ovulation induction in anovulatory women can lead to 9.4% reduction in the cost per live birth.124 Two separate economic analyses have demonstrated that uHMG is more cost-effective than rFSH in superovulation with IUI.159,160

Conclusion

Gene_expression (effective) of rFSH
19) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.05 Pain Relevance 0
An RCT which included 84 participants found no significant difference in pregnancy rate between poor responders treated with either rFSH alone or rLH and FSH in an GnRH agonist flare up protocol.107
Gene_expression (treated) of rFSH associated with agonist
20) Confidence 0.03 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.30 Pain Relevance 0.19

General Comments

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