INT276462

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.89
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (ULBP1) plasma membrane (ULBP1)
Anatomy Link Frequency
NK cell 3
ULBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 71.76 Quite High
palliative 4 65.48 Quite High
imagery 20 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 112 99.90 Very High Very High Very High
Metastasis 32 98.08 Very High Very High Very High
Cancer 460 95.84 Very High Very High Very High
Disease 40 95.64 Very High Very High Very High
Colon Cancer 84 87.48 High High
Liver Disease 4 86.56 High High
Death 16 78.40 Quite High
Necrosis 4 74.48 Quite High
Shock 8 59.08 Quite High
Malignant Neoplastic Disease 12 17.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we cannot exclude that the metastases succeeded to acquire an NK cell escape mechanism such as a down-regulated activatory NK ligand expression such as Hsp70, MICA/B or ULBP-1,2,3 or an up-regulation of inhibitory NK ligands such as HLA-E molecules [23,39].
Gene_expression (expression) of ULBP-1 in NK cell associated with metastasis
1) Confidence 0.17 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 1.06 Pain Relevance 0.03
The expression of ULBP-1 and -2 was lower than that of ULBP-3.
Gene_expression (expression) of ULBP-1
2) Confidence 0.17 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 1.07 Pain Relevance 0
The patient's anastomotic relapse did express a variety of ligands such as Hsp70, MICA-A/B, ULBP-1,2,3 which are recognized by activatory NK cell receptors.
Gene_expression (express) of ULBP-1 in NK cell associated with recurrence
3) Confidence 0.15 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 1.00 Pain Relevance 0.10
The NK cell ligands Hsp70, MICA/B, and ULBP-1,2,3 were expressed on the patient's anastomotic relapse.
Gene_expression (expressed) of ULBP-1 in NK cell associated with recurrence
4) Confidence 0.13 Published 2009 Journal J Transl Med Section Abstract Doc Link PMC2714296 Disease Relevance 0.76 Pain Relevance 0

General Comments

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