INT27651

Context Info Confidence 0.76 First Reported 1989 Last Reported 2010 Negated 7 Speculated 1 Reported most in Body Documents 45 Total Number 46 Disease Relevance 52.25 Pain Relevance 10.51

cytosol (S100A12) extracellular region (S100A12) nucleus (S100A12) cytoplasm (S100A12)

Anatomy Link Frequency neuron 5 granulocytes 3 smooth muscle 2 muscle 2 synovium 2 S100A12 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 413 100.00 Arthritis 412 99.54 rheumatoid arthritis 499 99.36 Crohn's disease 565 98.92 Enkephalin 1 98.72 Osteoarthritis 7 98.52 Snapping jaw 3 98.36 corticosteroid 58 97.12 spastic colon 385 97.04 Somatostatin 1 96.76

Disease Link Frequency Relevance Heat Disease 1422 100.00 INFLAMMATION 429 100.00 Cancer 425 99.86 Inflammatory Bowel Disease 1339 99.84 Nicotine Addiction 208 99.56 Seronegative Spondarthritis 356 99.54 Rheumatoid Arthritis 501 99.36 Fibroma 148 99.32 Chondrosarcoma 12 99.14 Osteoarthritis 7 98.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

S-100 protein was detected immunohistochemically in diseased human temporomandibular joint discs with different degrees of pathology, and the findings compared with those of normal discs.

Gene_expression (detected) of S-100 protein in temporomandibular joint associated with snapping jaw

1) Confidence 0.76 Published 2000 Journal Arch. Oral Biol. Section Abstract Doc Link 10739862 Disease Relevance 0.17 Pain Relevance 0.17

A very unusual feature of this case was positive staining for S-100 protein by sustentacular cells.

Gene_expression (staining) of S-100 protein in sustentacular cells

2) Confidence 0.67 Published 1995 Journal J Laryngol Otol Section Abstract Doc Link 7798009 Disease Relevance 0.53 Pain Relevance 0.09

This difference was more pronounced for S100A12 than for MRP8/14.

Gene_expression (pronounced) of S100A12

3) Confidence 0.67 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.90 Pain Relevance 0.40

Spearman correlation coefficients were used to explore the association of S100A12 with SAA and CRP values, CDAI and CAI, as well as disease duration.

Gene_expression (values) of S100A12 associated with disease

4) Confidence 0.67 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.54 Pain Relevance 0.09

S100A12 with respect to CRP and SAA levels

Gene_expression (levels) of S100A12

5) Confidence 0.67 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.31 Pain Relevance 0.22

A significant positive correlation was found between SAA and S100A12 (r = 0.22, P = 0.018) as well as between CRP and S100A12 (r = 0.35, P < 0.001).

Gene_expression (found) of S100A12

6) Confidence 0.67 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.05 Pain Relevance 0.27

S100A12 levels with focus on patients' characteristics

Gene_expression (levels) of S100A12

7) Confidence 0.67 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.30 Pain Relevance 0.09

Transcripts encoding the potent pro-inflammatory calgranulins proteins S100A8/9 and S100A12, characteristic of granulocyte neutrophil activity [51] and involved in a diversity of inflammatory diseases [56], as well as the granulocyte-related metalloprotease MMP8 are also over-expressed.

Gene_expression (expressed) of S100A12 in granulocyte associated with inflammation and disease

8) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.92 Pain Relevance 0.39

Moreover, a cut-off for serum S100A12 levels of 54.4 ng/mL could predict both UC and CD with a 66.7% sensitivity and a 64.4% specificity.

Gene_expression (levels) of S100A12 associated with inflammatory bowel disease and crohn's disease

9) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2964606 Disease Relevance 1.67 Pain Relevance 0.85

Considering the smoking habits of subjects in the IBD group, although at first glance, higher S100A12 serum levels in UC non-smokers (median: 72.4 ng/mL, range: 47.6-152.6 ng/mL) compared to UC current smokers were observed, this difference did not reach statistical significance (P = 0.215).

Gene_expression (levels) of S100A12 associated with inflammatory bowel disease and nicotine addiction

10) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.59 Pain Relevance 0.17

Considering standard activity indices, higher serum S100A12 levels in active compared to inactive IBD were observed, although the recorded difference did not reach statistical significance.

Gene_expression (levels) of S100A12 associated with inflammatory bowel disease

11) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2964606 Disease Relevance 1.67 Pain Relevance 0.88

What appears to be of interest is that a statistically significant association was found between serum S100A12 levels and the well-known markers of inflammation, CRP and SAA, in the absence of a similar association with IBD activity-determined by conventional inflammatory indices.

Gene_expression (levels) of S100A12 associated with inflammatory bowel disease and inflammation

12) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.66 Pain Relevance 0.28

The serum S100A12 levels determined in our population, using the prototypic ELISA described above, were lower compared to IBD-oriented studies, using different ELISA assays [7,8,10].

Gene_expression (levels) of S100A12 associated with inflammatory bowel disease

13) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.89 Pain Relevance 0.16

Serum S100A12 levels were also studied while considering disease activity.

Gene_expression (levels) of S100A12 associated with disease

14) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.08 Pain Relevance 0.55

As shown above, the levels of S100A12 in serum of current smokers, diagnosed with CD appeared to be elevated, compared to CD non-smokers.

Gene_expression (levels) of S100A12 associated with nicotine addiction and crohn's disease

15) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.90 Pain Relevance 0.31

Serum S100A12 levels were also examined with respect to the presence of one or more IBD-related extraintestinal manifestations.

Spec (examined) Gene_expression (levels) of S100A12 associated with inflammatory bowel disease

16) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.11 Pain Relevance 0.11

In that study, however, the levels of serum S100A12 in UC patients with inactive disease were comparable to those in healthy controls [8].

Gene_expression (levels) of S100A12 associated with inflammatory bowel disease and disease

17) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.66 Pain Relevance 0.18

In the UC group, the levels of serum S100A12 seemed to be higher in non-smokers than in those found in current smokers.

Gene_expression (levels) of S100A12 associated with inflammatory bowel disease and nicotine addiction

18) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.76 Pain Relevance 0.33

Finally, the levels of serum S100A12 did not seem to have any correlation with treatment modalities (5-ASA, corticosteroids, immunosuppressants, anti-TNF) (P > 0.05 in all cases) (Table 4).

Gene_expression (levels) of S100A12 associated with corticosteroid

19) Confidence 0.60 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.43 Pain Relevance 0.23

Based on the greater infiltration with PMCs in SpA than in RA, and a recent report on the granulocyte calcium-binding protein S100A12 in PsA [10], we assessed the expression of S100A12 in synovium of patients with PsA (n = 8), nonpsoriatic SpA (n = 12) and RA (n = 20; patient cohort 3; Table 3).

Gene_expression (expression) of S100A12 in synovium associated with rheumatoid arthritis and arthritis

20) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 1.36 Pain Relevance 0.57

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