INT276519

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Wt1) RNA binding (Wt1) nucleus (Wt1)
intracellular (Wt1) DNA binding (Wt1) cytoplasm (Wt1)
Anatomy Link Frequency
dendrites 1
Wt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 17.92 Low Low
withdrawal 2 16.72 Low Low
metalloproteinase 28 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 136 97.84 Very High Very High Very High
Cancer 59 92.76 High High
Desmoplastic Small Round Cell Tumor 1 91.20 High High
Leukemia 1 89.72 High High
Malignant Neoplastic Disease 11 86.68 High High
Death 1 67.72 Quite High
Apoptosis 23 64.28 Quite High
Solid Tumor 5 51.36 Quite High
Adhesions 11 51.12 Quite High
Pleurisy 1 18.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, while the findings we obtained were not successful in identifying novel WT1(+KTS) RNA targets, the mRNAs identified through microarray analysis revealed a surprising set of gene products with remarkably interrelated functions in maintenance of the actin cytoskeleton, including several with known important roles in podocytes as well as neuronal dendrites.
Regulation (targets) of WT1 in dendrites
1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
WT1 expression in MM correlates with expression of Syndecan-1 (Kumar-Singh 1998), but not of EGFR and IGFR, two transcriptional targets of WT1, or survival (Kumar-Singh, 1997).
Regulation (targets) of WT1 associated with lung cancer
2) Confidence 0.03 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.70 Pain Relevance 0

General Comments

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