INT276519

Context Info Confidence 0.24 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.70 Pain Relevance 0

nucleoplasm (Wt1) RNA binding (Wt1) nucleus (Wt1) intracellular (Wt1) DNA binding (Wt1) cytoplasm (Wt1)

Anatomy Link Frequency dendrites 1 Wt1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 1 17.92 withdrawal 2 16.72 metalloproteinase 28 5.00 chemokine 8 5.00 Nerve growth factor 4 5.00 cytokine 2 5.00 member 8 1 5.00 Angina 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Lung Cancer 136 97.84 Cancer 59 92.76 Desmoplastic Small Round Cell Tumor 1 91.20 Leukemia 1 89.72 Malignant Neoplastic Disease 11 86.68 Death 1 67.72 Apoptosis 23 64.28 Solid Tumor 5 51.36 Adhesions 11 51.12 Pleurisy 1 18.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, while the findings we obtained were not successful in identifying novel WT1(+KTS) RNA targets, the mRNAs identified through microarray analysis revealed a surprising set of gene products with remarkably interrelated functions in maintenance of the actin cytoskeleton, including several with known important roles in podocytes as well as neuronal dendrites.

Regulation (targets) of WT1 in dendrites

1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

WT1 expression in MM correlates with expression of Syndecan-1 (Kumar-Singh 1998), but not of EGFR and IGFR, two transcriptional targets of WT1, or survival (Kumar-Singh, 1997).

Regulation (targets) of WT1 associated with lung cancer

2) Confidence 0.03 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.70 Pain Relevance 0

General Comments

This test has worked.