INT27652

Context Info Confidence 0.78 First Reported 1987 Last Reported 2010 Negated 4 Speculated 0 Reported most in Body Documents 36 Total Number 36 Disease Relevance 22.36 Pain Relevance 2.74

signal transduction (TG) extracellular space (TG) extracellular region (TG) Golgi apparatus (TG) endoplasmic reticulum (TG)

Anatomy Link Frequency thyroid 10 neck 1 neuron 1 C cells 1 femur 1 TG (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 9 99.56 imagery 637 98.98 Enkephalin 1 98.72 Somatostatin 1 96.76 iatrogenic 2 95.92 abdominal pain 2 93.72 rheumatoid arthritis 3 92.00 alcohol 28 84.80 palliative 19 84.80 withdrawal 143 75.12

Disease Link Frequency Relevance Heat Thyroid Neoplasm 995 99.90 Disease 824 99.52 INFLAMMATION 66 99.44 Malignant Neoplastic Disease 95 99.20 Carcinoma 90 98.88 Metastasis 308 98.84 Cancer 703 97.80 Tremor 3 96.20 Hepatocellular Cancer 24 95.28 Toxicity 18 95.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On histological examination, the tall cell variant in the femur was producing abundant thyroglobulin.

Gene_expression (producing) of thyroglobulin in femur

1) Confidence 0.78 Published 2001 Journal Am. J. Med. Sci. Section Abstract Doc Link 11523623 Disease Relevance 0.57 Pain Relevance 0.07

It was not performed when serum thyroglobulin was detectable (?

Gene_expression (detectable) of thyroglobulin

2) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270902 Disease Relevance 0 Pain Relevance 0

Serum thyroglobulin levels were measured both while the patient was receiving levothyroxine and during TSH stimulation, which was achieved by abstaining from levothyroxine administration or by administering recombinant human TSH (rhTSH) for patients judged to tolerate abstaining from levothyroxine poorly (n?

Gene_expression (levels) of thyroglobulin

3) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270902 Disease Relevance 0 Pain Relevance 0

Thyroglobulin levels at the first and last 13-CRA RDT application are depicted in additional file 1: thyroglobulin before and after 13-CRA RDT.

Gene_expression (application) of Thyroglobulin

4) Confidence 0.66 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2739165 Disease Relevance 0.14 Pain Relevance 0.06

A double histochemical approach (Alcian blue-periodic acid-Schiff and Alcian blue-high-iron diamine) combined with ultrastructural investigation confirmed the presence of true mucus, ruling out the presence of breakdown products of thyroglobulin.

Gene_expression (products) of thyroglobulin

5) Confidence 0.60 Published 2000 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 11035596 Disease Relevance 0.49 Pain Relevance 0.07

Radioiodine ablation was repeated whenever serum thyroglobulin was detectable or when abnormal uptake was present in the thyroid bed or at extrathyroid sites in a diagnostic radioiodine scan.

Gene_expression (detectable) of thyroglobulin in thyroid

6) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270902 Disease Relevance 0.12 Pain Relevance 0

Last step was to determine if there was expression of cell-specific structures or receptors that are unique identifiers of cell types, for example neuroendocrine granules, peptide hormones, thyroglobulin, Prostate Specific Antigen (PSA), Gross Cystic Disease Fluid Protein (GCDFP) or Thyroid Transcription Factor-1 (TTF-1).

Gene_expression (expression) of thyroglobulin in Thyroid associated with disease

7) Confidence 0.58 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1310632 Disease Relevance 0.85 Pain Relevance 0

The groups with and without TSAb were comparable with regard to sex, age, anti-inflammatory drugs, serum thyroglobulin levels, antithyroglobulin and antimicrosomal antibodies, rheumatoid factor, as well as to the serum levels of thyroxine and 3, 5, 3'-triiodothyronine.

Gene_expression (levels) of thyroglobulin associated with inflammation and cinod

8) Confidence 0.58 Published 1987 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2892878 Disease Relevance 0.35 Pain Relevance 0.23

The use of RAI for all three purposes relies on the ability of both normal and malignant thyroid tissue to transport iodine for synthesis of thyroglobulin, triiodothyronine and thyroxine in response to TSH.

Gene_expression (synthesis) of thyroglobulin in thyroid associated with malignant neoplastic disease

9) Confidence 0.58 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0.73 Pain Relevance 0.07

Tg-on had become detectable in 1 of 14 patients, Tg and TSH levels did not significantly differ (p?

Gene_expression (detectable) of Tg-on

10) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950687 Disease Relevance 0.44 Pain Relevance 0.19

Tg-on was lower but remained detectable in both patients (table 3).

Gene_expression (detectable) of Tg-on

11) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950687 Disease Relevance 0.76 Pain Relevance 0.24

Tg-on after radiodine treatment remained detectable in one of both patients (2.6 ng/ml).

Gene_expression (detectable) of Tg-on

12) Confidence 0.53 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950687 Disease Relevance 0.39 Pain Relevance 0.16

Furthermore, immunoperoxidase stains for thyroglobulin and TTF-1 were negative, excluding the possibility of a thyroid neoplasm.

Neg (negative) Gene_expression (negative) of thyroglobulin in thyroid associated with thyroid neoplasm

13) Confidence 0.48 Published 2005 Journal Cytojournal Section Body Doc Link PMC1184093 Disease Relevance 0.64 Pain Relevance 0.09

Seventeen (95%) of 19 patients for whom serial thyroglobulin levels were available showed a marked and rapid response in thyroglobulin levels with a mean decrease of 70%.

Gene_expression (levels) of thyroglobulin

14) Confidence 0.47 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 0.83 Pain Relevance 0

Seventeen (95%) of 19 patients for whom serial thyroglobulin levels were available showed a marked and rapid response in thyroglobulin levels with a mean decrease of 70%.

Gene_expression (levels) of thyroglobulin

15) Confidence 0.47 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 0.78 Pain Relevance 0

-enkephalin, neuron-specific enolase, chromogranin and neurofilaments, and negative for thyroglobulin and S-100 protein.

Neg (negative) Gene_expression (negative) of thyroglobulin in neuron associated with enkephalin

16) Confidence 0.46 Published 1989 Journal Acta Cytol. Section Abstract Doc Link 2644744 Disease Relevance 0.66 Pain Relevance 0.15

Tg-on was undetectable in 115 patients.

Gene_expression (undetectable) of Tg-on

17) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950687 Disease Relevance 0.29 Pain Relevance 0.15

Group 3: Patients with undetectable Tg-on (<0.6 ng/ml)

Gene_expression (undetectable) of Tg-on

18) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950687 Disease Relevance 0.33 Pain Relevance 0.14

For it is known that lymph node metastases can be detected by neck ultrasound in patients with both undetectable Tg-on and undetectable rhTSH stimulated Tg or Tg-off [16], [17].

Gene_expression (undetectable) of Tg-on in neck associated with metastasis

19) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950687 Disease Relevance 0.82 Pain Relevance 0.05

Actually, this result only confirmed the already known absence of disease in these patients with undetectable Tg-on.

Gene_expression (undetectable) of Tg-on associated with disease

20) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950687 Disease Relevance 0.84 Pain Relevance 0.11

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