INT276526

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Myh10) plasma membrane (Myh10) cytoplasm (Myh10)
Myh10 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 8 5.00 Very Low Very Low Very Low
member 8 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 98.92 Very High Very High Very High
Stress 16 94.92 High High
Congenital Anomalies 4 86.76 High High
Renal Disease 24 78.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 77.76 Quite High
Adhesions 12 73.20 Quite High
Nephrotic Syndrome 32 70.56 Quite High
Renal Failure 12 5.00 Very Low Very Low Very Low
Chronic Renal Failure 12 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, another of our highly enriched mRNAs, that encoding myosin IIb (Myh10) has been shown to be overexpressed in a number of glomerular disease models (e.g. [45]).
Gene_expression (overexpressed) of Myh10 associated with disease
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.51 Pain Relevance 0
By contrast, another of our highly enriched mRNAs, that encoding myosin IIb (Myh10) has been shown to be overexpressed in a number of glomerular disease models (e.g. [45]).
Gene_expression (overexpressed) of myosin IIb associated with disease
2) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.51 Pain Relevance 0
While not all of these proteins were specifically shown to be TRPC6 binding proteins in this publication, one of the authors reports that at least eight, Spna2, Spnb2, Myh9, Myh10, Actn1, Acnt4, Dbn1, Gsn, do also specifically co-IP with TRPC6 (W.P.
Gene_expression (eight) of Myh10
3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.37 Pain Relevance 0
Importantly, Western blots comparing input and purified eluate samples probing for Myh10, Dbn1, and IQGAP1 demonstrated little or no protein present in the purified eluate samples, compared to strong signals in the input samples (data not shown).
Gene_expression (probing) of Myh10
4) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

General Comments

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