INT276530

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Wt1) RNA binding (Wt1) nucleus (Wt1)
intracellular (Wt1) DNA binding (Wt1) cytoplasm (Wt1)
Anatomy Link Frequency
bands 1
foot 1
podocyte 1
body 1
Wt1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 6.48 Low Low
withdrawal 6 5.00 Very Low Very Low Very Low
member 8 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frasier Syndrome 6 99.82 Very High Very High Very High
Renal Failure 9 96.36 Very High Very High Very High
Chronic Myelomonocytic Leukemia 1 95.48 Very High Very High Very High
Mesothelioma 79 95.40 Very High Very High Very High
Malignant Neoplastic Disease 10 94.56 High High
Myelofibrosis 1 90.60 High High
Myelodysplastic Syndromes 7 89.84 High High
Cancer 79 89.72 High High
Leukemia 10 89.12 High High
Severe Combined Immunodeficiency 4 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, mice with complete absence of WT1(+KTS) develop abnormal podocyte morphology and impaired foot process formation leading to renal failure [24].
Negative_regulation (absence) of WT1 in foot associated with renal failure
1) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.30 Pain Relevance 0
g/body) of WT1 peptides could generate a WT1-specific CTL response and lead to a reduction of the WT1 transcript level 21.
Negative_regulation (reduction) of WT1 in body
2) Confidence 0.39 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 1.09 Pain Relevance 0
Evidence that the WT1(+KTS) isoform has important roles in podocyte function is provided by WT1 mutations in patients with Frasier syndrome cause a reduction in relative levels of the WT1(+KTS) isoform.
Negative_regulation (reduction) of WT1 in podocyte associated with frasier syndrome
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.45 Pain Relevance 0
These bands represent those submitted for mass spectrometry analysis and therefore their presence in the eluates was not only independent of WT1(+KTS), but also did not specifically require elution with TEV protease (Figure 4A).
Neg (independent) Negative_regulation (independent) of WT1 in bands
4) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
Xenografts were strongly positive for calretinin and moderately positive for D2-40, mesothelin and WT-1 (Fig. 2).
Negative_regulation (positive) of WT-1
5) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2850899 Disease Relevance 1.13 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox