INT276537

Context Info Confidence 0.65 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.16 Pain Relevance 0

cell proliferation (Myh10) plasma membrane (Myh10) cytoplasm (Myh10)

Anatomy Link Frequency diaphragm 1 podocyte 1 Myh10 (Mus musculus)

Pain Link Frequency Relevance Heat withdrawal 4 5.00 member 8 2 5.00

Disease Link Frequency Relevance Heat Disease 22 88.88 Nephrotic Syndrome 16 5.00 Renal Disease 12 5.00 Stress 8 5.00 Adhesions 6 5.00 Renal Failure 6 5.00 Chronic Renal Failure 6 5.00 Injury 6 5.00 Syndrome 6 5.00 Cancer 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since 7 of these proteins (as well as Myh10) have been shown to be localized to podocyte foot processes, these collective observations raise an interesting speculation that a number of the RNA transcripts we identified may similarly be localized at the slit diaphragm.

Localization (localized) of Myh10 in diaphragm

1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

Eight of encoded proteins have been directly shown to localize to the podocyte foot processes, including the slit diaphragm: myosin IIa (Myh9), myosin IIb (Myh10), drebrin (Dbn1), spectrin-?

Localization (localize) of myosin IIb in podocyte

2) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.