INT276550

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Wt1) RNA binding (Wt1) nucleus (Wt1)
intracellular (Wt1) DNA binding (Wt1) cytoplasm (Wt1)
Anatomy Link Frequency
T cells 2
Wt1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 54 94.12 High High
Myelodysplastic Syndromes 14 93.80 High High
Chronic Myelomonocytic Leukemia 2 78.92 Quite High
Myelofibrosis 2 74.04 Quite High
Recurrence 2 73.44 Quite High
Leukemia 20 72.56 Quite High
Disease 17 72.24 Quite High
Cancer 27 53.24 Quite High
Stress 4 14.20 Low Low
Congenital Anomalies 1 6.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They demonstrated that the post-vaccination emergence of PR1 or WT1-specific CD8+ T cells was associated with a decrease in WT1 mRNA expression.
Transcription (expression) of WT1 in T cells
1) Confidence 0.66 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 1.29 Pain Relevance 0
Thus, despite the identification of a previously described WT1(+KTS) target mRNA in the results and the remarkable physiologically relevant functions of the encoded proteins, these results established that their identification was not due to WT1(+KTS) binding as envisioned by the experimental design.


Transcription (described) of WT1
2) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
Although WT1/MHC tetramer+CD8+ T cells were not detected in PB before the WT1 peptide vaccination, WT1/MHC tetramer+CD8+ T cells appeared after the second vaccination.
Neg (not) Transcription (detected) of WT1 in T cells
3) Confidence 0.49 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.05 Pain Relevance 0

General Comments

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