INT276553

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Context Info
Confidence 0.60
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Actn4) nucleus (Actn4) protein complex (Actn4)
cytoplasm (Actn4)
Anatomy Link Frequency
spines 1
podocytes 1
Actn4 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 6 5.00 Very Low Very Low Very Low
member 8 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 33 98.20 Very High Very High Very High
Adhesions 9 34.00 Quite Low
Nephrotic Syndrome 24 19.60 Low Low
Renal Disease 18 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Renal Failure 9 5.00 Very Low Very Low Very Low
Chronic Renal Failure 9 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Syndrome 9 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, biochemical purification of Actn4 identified Myh9 as the predominant interacting protein, suggesting that interactions between these proteins are a part of a protein interaction network in podocytes that underlie maintenance of structural cytoskeletal integrity [38].
Gene_expression (identified) of Actn4 in podocytes
1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.17 Pain Relevance 0
Notably in the list of genes that passed the 15% FDR, three positive probesets for Actn4 were present in the top 30 ranked probesets, providing strong evidence of reproducible enrichment.
Gene_expression (present) of Actn4
2) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.14 Pain Relevance 0
It is worth noting in the context of analogies between the podocyte slit diaphragm and neuronal dendrites that numerous mRNAs that encode dendritic proteins are themselves localized to dendritic spines where they appear to be dynamically translated at their sites of expression [60] Just as a number of the proteins encoded by these mRNA are localized to dendrites, it is also noteworthy that 15 of the enriched mRNAs themselves have been shown to localize to dendritic spines, the post-synaptic density, or (in one case) at the post-synaptic membrane of the neuromuscular junction: Ppp1r9b, Dbn1, Myh9, Plec1, Spna2, Spnb2, Actn4, Actn1, Gsn, Nes, Pls3, Utrn, Dst, Myo1b, Shrm [61]–[69].
Gene_expression (expression) of Actn4 in spines
3) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

General Comments

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