INT276555

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Context Info
Confidence 0.59
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Actn1) cytoskeleton (Actn1) nucleus (Actn1)
cytoplasm (Actn1)
Anatomy Link Frequency
spines 1
Actn1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 6 5.00 Very Low Very Low Very Low
member 8 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 33 81.20 Quite High
Adhesions 9 73.20 Quite High
Stress 12 72.64 Quite High
Nephrotic Syndrome 24 70.56 Quite High
Congenital Anomalies 3 64.48 Quite High
Renal Disease 18 58.80 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 55.48 Quite High
Renal Failure 9 5.00 Very Low Very Low Very Low
Chronic Renal Failure 9 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While not all of these proteins were specifically shown to be TRPC6 binding proteins in this publication, one of the authors reports that at least eight, Spna2, Spnb2, Myh9, Myh10, Actn1, Acnt4, Dbn1, Gsn, do also specifically co-IP with TRPC6 (W.P.
Gene_expression (eight) of Actn1
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.38 Pain Relevance 0
Two positive probesets for Actn1 were present in the top 88 ranked probesets.
Gene_expression (present) of Actn1
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.38 Pain Relevance 0
It is worth noting in the context of analogies between the podocyte slit diaphragm and neuronal dendrites that numerous mRNAs that encode dendritic proteins are themselves localized to dendritic spines where they appear to be dynamically translated at their sites of expression [60] Just as a number of the proteins encoded by these mRNA are localized to dendrites, it is also noteworthy that 15 of the enriched mRNAs themselves have been shown to localize to dendritic spines, the post-synaptic density, or (in one case) at the post-synaptic membrane of the neuromuscular junction: Ppp1r9b, Dbn1, Myh9, Plec1, Spna2, Spnb2, Actn4, Actn1, Gsn, Nes, Pls3, Utrn, Dst, Myo1b, Shrm [61]–[69].
Gene_expression (expression) of Actn1 in spines
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

General Comments

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