INT276576

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.75
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bands 1
foot 1
podocyte 1
KTWS (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 6 5.00 Very Low Very Low Very Low
member 8 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frasier Syndrome 6 99.82 Very High Very High Very High
Renal Failure 9 96.56 Very High Very High Very High
Cancer 9 57.32 Quite High
Nephrotic Syndrome 24 53.08 Quite High
Denys-drash Syndrome 3 50.48 Quite High
Wilms Tumor 3 45.52 Quite Low
Disease 33 41.96 Quite Low
Chronic Renal Failure 9 34.36 Quite Low
Diabetes Mellitus 3 34.16 Quite Low
Syndrome 9 20.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence that the WT1(+KTS) isoform has important roles in podocyte function is provided by WT1 mutations in patients with Frasier syndrome cause a reduction in relative levels of the WT1(+KTS) isoform.
Negative_regulation (reduction) of KTS in podocyte associated with frasier syndrome
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.45 Pain Relevance 0
Similarly, mice with complete absence of WT1(+KTS) develop abnormal podocyte morphology and impaired foot process formation leading to renal failure [24].
Negative_regulation (absence) of KTS in foot associated with renal failure
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.30 Pain Relevance 0
These bands represent those submitted for mass spectrometry analysis and therefore their presence in the eluates was not only independent of WT1(+KTS), but also did not specifically require elution with TEV protease (Figure 4A).
Neg (independent) Negative_regulation (independent) of KTS in bands
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

General Comments

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