INT276577

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 3
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

KTWS (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 8 5.00 Very Low Very Low Very Low
member 8 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 68.28 Quite High
Stress 16 59.72 Quite High
Congenital Anomalies 4 51.56 Quite High
Renal Disease 24 43.48 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 42.56 Quite Low
Nephrotic Syndrome 32 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low
Renal Failure 12 5.00 Very Low Very Low Very Low
Chronic Renal Failure 12 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results were highly reproducible and thus the enrichment of Myh10 in the pulldowns using empty vector control extracts clearly indicated that the enrichment of this mRNA did not require an association with WT1(+KTS).
Neg (not) Positive_regulation (require) of KTS Neg (not) Binding (association) of
1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
However, we were surprised to find that in subsequent validations, we detemined that the enrichment these mRNAs was clearly not due to association with WT1(+KTS).
Neg (not) Positive_regulation (due) of KTS Binding (association) of
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.18 Pain Relevance 0
Further validation experiments using qRT-PCR were carried out to more definitively determine whether the enrichment of these mRNAs was specifically due to association with WT1(+KTS).
Spec (whether) Positive_regulation (due) of KTS Binding (association) of
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.11 Pain Relevance 0
Thus, despite the identification of a previously described WT1(+KTS) target mRNA in the results and the remarkable physiologically relevant functions of the encoded proteins, these results established that their identification was not due to WT1(+KTS) binding as envisioned by the experimental design.


Neg (not) Positive_regulation (due) of KTS Binding (binding) of
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

General Comments

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