INT276620

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Context Info
Confidence 0.57
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 26
Disease Relevance 6.48
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Anatomy Link Frequency
goblet cell 3
intestinal epithelium 2
small intestine 2
colon 1
villus 1
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 60 99.00 Very High Very High Very High
Nicotine 121 98.56 Very High Very High Very High
Crohn's disease 180 96.56 Very High Very High Very High
cytokine 16 84.40 Quite High
addiction 20 71.72 Quite High
noradrenaline 6 62.08 Quite High
COX-2 inhibitor 4 48.08 Quite Low
anesthesia 22 5.00 Very Low Very Low Very Low
cINOD 20 5.00 Very Low Very Low Very Low
isoflurane 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 150 99.68 Very High Very High Very High
Death 44 99.48 Very High Very High Very High
Disease 253 99.36 Very High Very High Very High
INFLAMMATION 56 99.00 Very High Very High Very High
Adhesions 69 98.44 Very High Very High Very High
Infection 107 98.40 Very High Very High Very High
Volume Depletion And Dehydration 20 97.84 Very High Very High Very High
Diarrhoea 44 97.68 Very High Very High Very High
Apoptosis 243 97.28 Very High Very High Very High
Congenital Anomalies 32 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest a perturbation of Paneth and goblet cell maturation and migration after loss of E-cadherin.
Negative_regulation (loss) of E-cadherin in goblet cell
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.06 Pain Relevance 0
It may be due to the relatively short period of time between start of recombination and analysis of mice in our model and the fact that loss of E-cadherin occurred in the adult mouse and not during embryogenesis.
Negative_regulation (loss) of E-cadherin in adult mouse
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.23 Pain Relevance 0
After loss of E-cadherin, lysozyme and MMP7 positive cells were no longer confined to this location but were scattered all over the crypts and villi in Cre+Cdh1fl/fl mice (Fig. 3E and F, right panels).
Negative_regulation (loss) of E-cadherin
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0 Pain Relevance 0
This stands in contrast to our findings, where loss of E-cadherin does not affect the ultrastructure of tight junctions, but results in loss of desmosomes.
Negative_regulation (loss) of E-cadherin
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.18 Pain Relevance 0
To determine the status of Wnt signaling after loss of E-cadherin in more detail in situ hybridization for the target gene Axin2 (Fig. 6C–E) was performed.
Negative_regulation (loss) of E-cadherin
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0 Pain Relevance 0
Here, loss of E-cadherin resulted in death of mice shortly after birth due to dehydration [41], altered differentiation [39], and disturbed epidermal integrity [40].
Negative_regulation (loss) of E-cadherin associated with volume depletion and dehydration and death
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.20 Pain Relevance 0
As the severe changes of the intestinal epithelium caused by loss of E-cadherin were not compatible with life, precluding a more detailed study of E-cadherin's role in differentiation and localization of cells, a milder recombination protocol allowing mice to survive for a longer period was developed.
Negative_regulation (loss) of E-cadherin in intestinal epithelium
7) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.06 Pain Relevance 0
Impairment of bacterial defense after loss of E-cadherin
Negative_regulation (loss) of E-cadherin
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.06 Pain Relevance 0
As loss of E-cadherin affected localization of differentiated cells, cell migration was studied in more detail.
Negative_regulation (loss) of E-cadherin
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.06 Pain Relevance 0
To genetically clarify the function of E-cadherin in intestinal homeostasis and maintenance of the epithelial defense line, the Cdh1 gene was conditionally inactivated in the mouse intestinal epithelium.
Negative_regulation (inactivated) of Cdh1 in intestinal epithelium
10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001873 Disease Relevance 0.45 Pain Relevance 0.05
The simultaneous appearance of incompletely differentiated, mispositioned cells and of normally differentiated cells is most likely due to the coexistence of E-cadherin deficient and E-cadherin expressing cells owing to incomplete recombination in the extended tamoxifen injection protocol.
Negative_regulation (deficient) of E-cadherin
11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.05 Pain Relevance 0
These mice displayed a decrease and intracellular redistribution of E-cadherin, suggesting a role for E-cadherin in intestinal homeostasis.
Negative_regulation (decrease) of E-cadherin
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.32 Pain Relevance 0.04
Down-regulation of E-cadherin is associated with the pathogenesis of infections with enteropathogenic bacteria and Crohn's disease.


Negative_regulation (regulation) of E-cadherin associated with crohn's disease, disease and infection
13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001873 Disease Relevance 0.39 Pain Relevance 0.05
Inactivation of the Cdh1 gene in the small intestine and colon resulted in bloody diarrhea associated with enhanced apoptosis and cell shedding, causing life-threatening disease within 6 days.
Negative_regulation (Inactivation) of Cdh1 in small intestine associated with diarrhoea, disease and apoptosis
14) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001873 Disease Relevance 0.47 Pain Relevance 0.05
Induction of cell death and loss of adherens junctions and differentiated cells upon loss of E-cadherin
Negative_regulation (loss) of E-cadherin associated with death
15) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.58 Pain Relevance 0
E-cadherin deficiency abrogates localization and maturation of secretory cells
Negative_regulation (deficiency) of E-cadherin in secretory cells
16) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.05 Pain Relevance 0
Loss of E-cadherin led cells migrate faster along the crypt-villus axis and perturbed cellular differentiation.
Negative_regulation (Loss) of E-cadherin in villus
17) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001873 Disease Relevance 0.46 Pain Relevance 0.04
Loss of E-cadherin might either result in a defect in cell sorting allowing common Paneth and goblet cell precursors to migrate along the crypt-villus axis where they are no longer exposed to Wnt signals coinciding with impaired maturation, or E-cadherin might be required for anchoring and maturation of Paneth cells at the base of the crypts.
Negative_regulation (Loss) of E-cadherin in goblet cell
18) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0 Pain Relevance 0
Loss of E-cadherin compromises Paneth and goblet cell maturation
Negative_regulation (Loss) of E-cadherin in goblet cell
19) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0 Pain Relevance 0
Furthermore, RT-PCR analysis demonstrated reduced E-cadherin RNA levels in gluten-sensitized plus indomethacin treated mice.
Negative_regulation (reduced) of E-cadherin
20) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.48 Pain Relevance 0.03

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