INT276649

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2009
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Polg) aging (Polg)
Anatomy Link Frequency
bars 1
Polg (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 12 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 65 99.28 Very High Very High Very High
Lymphatic System Cancer 44 88.48 High High
Leukemia 21 88.12 High High
Targeted Disruption 1 50.00 Quite Low
Disease 13 21.04 Low Low
Aging 8 8.00 Low Low
Sprains And Strains 11 5.00 Very Low Very Low Very Low
Frailty 6 5.00 Very Low Very Low Very Low
Precursor Cell Lymphoblastic Leukemia-lymphoma 6 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of POLG and LIG3 proteins were not evaluated due to the lack of adequate antibodies.


Gene_expression (levels) of POLG
1) Confidence 0.70 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2715231 Disease Relevance 0 Pain Relevance 0
It may be that Polg and Lig3 expression reflects the lower mtDNA levels apparent during the recovery phase and that mtDNA packaging is altered during this process leading to no change in Tfam levels.
Gene_expression (expression) of Polg
2) Confidence 0.70 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2715231 Disease Relevance 0 Pain Relevance 0
(C) The mtDNA/nDNA ratios (dark gray bars) were correlated to the transcript levels of POLG, LIG3 and TFAM (filled circles in each sub-panel).
Gene_expression (levels) of POLG in bars
3) Confidence 0.54 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2715231 Disease Relevance 0 Pain Relevance 0
This suggests that the decrease in expression of Polg and Lig3 was related to the type of mtDNA damage i.e.
Gene_expression (expression) of Polg
4) Confidence 0.54 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2715231 Disease Relevance 0 Pain Relevance 0
The transcript levels of Polg and Lig3 (solid circles on Figure 2), evaluated by Real Time PCR, were unchanged compared to the levels observed in non-induced (NI) samples; however, at 9 days post induction, the levels of both these transcripts were significantly decreased.
Gene_expression (levels) of Polg
5) Confidence 0.54 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2715231 Disease Relevance 0 Pain Relevance 0
The expression of three genes involved in mtDNA metabolism were investigated in the same model system, Polg, Lig3 and Tfam.
Spec (investigated) Gene_expression (expression) of Polg
6) Confidence 0.21 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2715231 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry experiments confirmed these results, since all tumors sections analyzed displayed higher expression levels of the proliferating cell nuclear antigen (PCNA), a processivity factor for DNA polymerase ?
Spec (analyzed) Gene_expression (expression) of polymerase associated with cancer
7) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.31 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox