INT276676

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.82
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Prkcg (Rattus norvegicus)
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.8 130 100.00 Very High Very High Very High
Kinase C 76 100.00 Very High Very High Very High
Inflammation 20 98.44 Very High Very High Very High
dorsal root ganglion 86 97.20 Very High Very High Very High
substance P 132 95.88 Very High Very High Very High
IPN 6 91.88 High High
addiction 6 83.08 Quite High
tetrodotoxin 34 71.76 Quite High
Pain 22 66.96 Quite High
Spinal cord 8 64.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 22 98.44 Very High Very High Very High
Ganglion Cysts 90 97.20 Very High Very High Very High
Inflammatory Pain 6 91.88 High High
Nociception 6 71.76 Quite High
Pain 26 66.96 Quite High
Hyperalgesia 10 26.64 Quite Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Rupture 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given modulation of Nav1.8 by PKC [23,24,29], here we used bisindolylmaleimide (BIM), a PKC inhibitor, to examine its effect on the Sar-SP-induced potentiation of Nav1.8 currents.
PKC Regulation (modulation) of Nav1.8 associated with kinase c, nav1.8 and substance p
1) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.14 Pain Relevance 1.47
Therefore, we assume that the modulation of Nav1.8 by NK-1 via PKC?
PKC Regulation (modulation) of Nav1.8 associated with kinase c and nav1.8
2) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.68 Pain Relevance 1.81

General Comments

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