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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg, Trpv1) nucleus (Prkcg, Nkx1-1) plasma membrane (Prkcg, Trpv1)
intracellular (Prkcg) lipid metabolic process (Trpv1) response to stress (Prkcg)
Prkcg (Rattus norvegicus)
Nkx1-1 (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 38 100.00 Very High Very High Very High
nav1.8 65 95.80 Very High Very High Very High
Pain 11 87.72 High High
Peripheral sensitization 1 87.40 High High
substance P 66 84.88 Quite High
calcitonin gene related peptide 1 78.96 Quite High
Neuropeptide 2 77.68 Quite High
hyperexcitability 1 59.96 Quite High
Action potential 7 57.88 Quite High
tetrodotoxin 17 50.08 Quite High
Disease Link Frequency Relevance Heat
Pain 13 87.72 High High
Ganglion Cysts 45 50.00 Quite Low
Inflammatory Pain 3 43.60 Quite Low
Neuropathic Pain 3 42.40 Quite Low
Hyperalgesia 5 41.80 Quite Low
INFLAMMATION 11 36.64 Quite Low
Nociception 3 28.28 Quite Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Rupture 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with our previous finding that the modulation of TRPV1 by NK-1 receptor was mediated by activation of PLC and downstream PKC pathway [9], the present results also proved the involvement of PKC in the interaction between NK-1 and Nav1.8.
Positive_regulation (activation) of PKC Positive_regulation (mediated) of NK-1 Regulation (modulation) of TRPV1 associated with kinase c and nav1.8
1) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.16 Pain Relevance 1.46

General Comments

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