INT27671

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.25
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
lateral preoptic area 3
brain 2
medial 1
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 6 100.00 Very High Very High Very High
Morphine 5 100.00 Very High Very High Very High
narcan 4 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
Endogenous opioid 2 71.68 Quite High
opioid receptor 1 61.60 Quite High
Neuropeptide 1 48.08 Quite Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 94.08 High High
Precocious Puberty 43 50.00 Quite Low
Disease 2 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 1 5.00 Very Low Very Low Very Low
Central Nervous System Cancer 1 5.00 Very Low Very Low Very Low
Hamartoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of herb mixture on GnRH mRNA expression by RT-PCR
Regulation (Effects) of Transcription (expression) of GnRH
1) Confidence 0.45 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.06 Pain Relevance 0
We detected no significant change with puberty in GnRH mRNA signal levels in any of the anatomical areas examined, which included the vertical limb of the diagonal band of Broca, medial septum, lateral preoptic area, and medial preoptic area.
Neg (no) Regulation (change) of Transcription (levels) of GnRH in lateral preoptic area associated with urological neuroanatomy
2) Confidence 0.27 Published 1989 Journal Endocrinology Section Abstract Doc Link 2647464 Disease Relevance 0.09 Pain Relevance 0.19
In order to investigate the role of opiates in the regulation of GnRH gene expression in the rat brain, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on GnRH mRNA levels as measured by in situ hybridization.
Regulation (effects) of Transcription (levels) of GnRH in brain associated with antagonist, narcan, opiate, opioid and morphine
3) Confidence 0.26 Published 1993 Journal Neuroreport Section Abstract Doc Link 8477057 Disease Relevance 0 Pain Relevance 1.14
We detected no significant change with puberty in GnRH mRNA signal levels in any of the anatomical areas examined, which included the vertical limb of the diagonal band of Broca, medial septum, lateral preoptic area, and medial preoptic area.
Neg (no) Regulation (change) of in medial Transcription (levels) of GnRH in lateral preoptic area associated with urological neuroanatomy
4) Confidence 0.09 Published 1989 Journal Endocrinology Section Abstract Doc Link 2647464 Disease Relevance 0.09 Pain Relevance 0.19

General Comments

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