INT276759

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TOP2A) nuclear chromosome (TOP2A) transport (ABCB1)
aging (TOP2A) chromosome segregation (TOP2A) enzyme binding (TOP2A)
ABCB1 (Homo sapiens)
TOP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuronal excitability 2 45.80 Quite Low
cocaine 2 39.36 Quite Low
Crohn's disease 14 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
endometriosis 6 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 97.96 Very High Very High Very High
Cancer 36 84.64 Quite High
Disease 262 67.20 Quite High
Nicotine Addiction 2 35.32 Quite Low
Ataxia 14 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Skin Cancer 8 5.00 Very Low Very Low Very Low
Endometriosis (extended) 8 5.00 Very Low Very Low Very Low
Keratosis 8 5.00 Very Low Very Low Very Low
Nevus 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Doxorubicin targets topoisomerase II alpha (TOP2A), which is involved in the biological pathways of apoptotic DNA fragmentation and G2/M DNA damage checkpoint regulation in cell cycle [57].
Doxorubicin Regulation (targets) of topoisomerase II alpha associated with apoptosis
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715883 Disease Relevance 0.30 Pain Relevance 0
Doxorubicin targets topoisomerase II alpha (TOP2A), which is involved in the biological pathways of apoptotic DNA fragmentation and G2/M DNA damage checkpoint regulation in cell cycle [57].
Doxorubicin Regulation (targets) of TOP2A associated with apoptosis
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715883 Disease Relevance 0.31 Pain Relevance 0

General Comments

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