INT276842

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.32
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
brain 4
DRG 2
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 84 99.78 Very High Very High Very High
Pain 40 99.68 Very High Very High Very High
bradykinin 3 98.98 Very High Very High Very High
Serotonin 5 98.30 Very High Very High Very High
Nerve growth factor 9 98.06 Very High Very High Very High
Inflammatory mediators 3 97.38 Very High Very High Very High
IPN 42 91.76 High High
vanilloid receptor subtype 1 1 91.48 High High
nociceptor 9 89.36 High High
ischemia 8 85.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 89 99.78 Very High Very High Very High
Pain 40 99.68 Very High Very High Very High
Inflammatory Pain 42 91.76 High High
Acidosis 30 87.64 High High
Hematoma 2 85.92 High High
Cv Unclassified Under Development 4 85.48 High High
Infection 7 85.08 High High
Nociception 9 81.48 Quite High
Hyperalgesia 27 74.36 Quite High
Cancer 5 52.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, inflammatory mediators, such as nerve growth factor (NGF), serotonin (5-HT), interleukin-1, bradykinin, and brain-derived neurotrophic factor (BDNF) can stimulate ASIC3 transcription, which perhaps contributes to the pain-enhancing effects of these mediators [49,50].
Positive_regulation (stimulate) of Transcription (transcription) of ASIC3 in brain associated with pain, inflammatory mediators, nerve growth factor, bradykinin and serotonin
1) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.02 Pain Relevance 0.94
Additionally, inflammatory mediators, such as nerve growth factor (NGF), serotonin (5-HT), interleukin-1, bradykinin, and brain-derived neurotrophic factor (BDNF) can stimulate ASIC3 transcription, which perhaps contributes to the pain-enhancing effects of these mediators [49,50].
Positive_regulation (contributes) of Transcription (transcription) of ASIC3 in brain associated with pain, inflammatory mediators, nerve growth factor, bradykinin and serotonin
2) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.08 Pain Relevance 0.94
With peripheral inflammation, the mRNA expression of TRPV1 and ASIC3 is increased in dorsal root ganglia (DRG) and sensitizes their responses [15-20].
Positive_regulation (increased) of Transcription (expression) of ASIC3 in DRG associated with inflammation
3) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.22 Pain Relevance 1.06

General Comments

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