INT276855

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2009
Negated 0
Speculated 4
Reported most in Body
Documents 1
Total Number 28
Disease Relevance 17.04
Pain Relevance 16.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr65) plasma membrane (Gpr65) signal transducer activity (Gpr65)
Anatomy Link Frequency
neurons 24
IB4 10
immune cell 2
Gpr65 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1400 100.00 Very High Very High Very High
qutenza 1232 99.70 Very High Very High Very High
Hyperalgesia 644 99.48 Very High Very High Very High
IPN 784 99.40 Very High Very High Very High
nociceptor 196 98.16 Very High Very High Very High
Thermal hyperalgesia 112 98.08 Very High Very High Very High
Kinase C 252 96.20 Very High Very High Very High
ASIC 56 95.92 Very High Very High Very High
Pain 392 90.32 High High
withdrawal 280 87.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1428 100.00 Very High Very High Very High
Hyperalgesia 756 99.48 Very High Very High Very High
Inflammatory Pain 784 99.40 Very High Very High Very High
Pressure And Volume Under Development 588 94.72 High High
Apoptosis 28 94.40 High High
Nociception 252 90.36 High High
Pain 448 90.32 High High
Neuropathic Pain 28 78.80 Quite High
Erythema 28 77.76 Quite High
Acidosis 56 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased TDAG8 expression in IB4-positive neurons after peripheral inflammation may increase the sensitivity of IB4-positive neurons to proton and capsaicin, through modulating the functions of ASICs or TRPV1.
Positive_regulation (Increased) of Gene_expression (expression) of TDAG8 in IB4 associated with qutenza, inflammation and asic
1) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.56 Pain Relevance 1.02
Although TDAG8 expression is required for the production of cAMP in immune cells, mice lacking TDAG8 have normal immune cell development [43,44].
Positive_regulation (required) of Gene_expression (expression) of TDAG8 in immune cell
2) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.88 Pain Relevance 0.60
Accordingly, TDAG8-expressing neurons were increased in number in both IB4-positive and -negative populations after CFA injection.


Positive_regulation (increased) of Gene_expression (expressing) of TDAG8 in IB4
3) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.16 Pain Relevance 0.16
At 24 hours after carrageenan injection, GPR4, TDAG8 and G2A expression increased (1.4~2.2-fold for GPR4, 1.4~2.1-fold for G2A, and 1.4~1.9-fold for TDAG8; Fig. 2B).
Positive_regulation (increased) of Gene_expression (expression) of TDAG8
4) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.68 Pain Relevance 0.35
In small-diameter neurons, TDAG8-expressing neurons were increased in number in both IB4-positive and -negative nociceptors.
Positive_regulation (increased) of Gene_expression (expressing) of TDAG8 in IB4 associated with nociceptor
5) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.60 Pain Relevance 0.83
Given that IB4-positive neurons had more TDAG8 expression than IB4-negative neurons after CFA-injection, the enhanced sensitivity of IB4-positive neurons to capsaicin may be due to increased TDAG8 expression.
Positive_regulation (increased) of Gene_expression (expression) of TDAG8 in neurons associated with qutenza
6) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.17 Pain Relevance 0.73
TDAG8-expressing neurons were also increased in number in the IB4-negative population (12 ± 3% and 21 ± 4% for the contralateral and ipsilateral DRGs, respectively) (Fig. 5B, Table 2).
Positive_regulation (increased) of Gene_expression (expressing) of TDAG8 in IB4
7) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.15 Pain Relevance 0.16
TDAG8-expressing neurons were increased in number in small- and large-diameter neuron populations.
Positive_regulation (increased) of Gene_expression (expressing) of TDAG8 in neuron
8) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.07 Pain Relevance 0.06
The plasticity of A-fiber neurons is an important mechanism that causes hyperalgesia following inflammation, therefore, increased TDAG8 expression in A-fiber could be involved in mechanical and thermal hyperalgesia by regulating TRPV1 function.
Positive_regulation (increased) of Gene_expression (expression) of TDAG8 in neurons associated with hyperalgesia, inflammation and thermal hyperalgesia
9) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.56 Pain Relevance 0.69
Enhanced mRNA levels were due to an increase in the total number of neurons expressing TDAG8.
Positive_regulation (increase) of Gene_expression (expressing) of TDAG8 in neurons
10) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.70 Pain Relevance 0.42
Whether increased TDAG8 expression enhances TDAG8 function after inflammation has remained unclear.
Spec (Whether) Positive_regulation (increased) of Gene_expression (expression) of TDAG8 associated with inflammation
11) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.22 Pain Relevance 0.15
GPR4, G2A, and TDAG8 transcripts were increased in levels 24 hours after carrageenan injection, but only TDAG8 expression was increased after CFA injection.
Positive_regulation (increased) of Gene_expression (expression) of TDAG8
12) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.01 Pain Relevance 0.94
At 24 hours after CFA injection, only TDAG8 expression was increased greatly (2.5~4.3-fold), but the level was reduced at 72 hours (1.2~1.6-fold) (Fig. 2C).
Positive_regulation (increased) of Gene_expression (expression) of TDAG8
13) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.61 Pain Relevance 0.33
To further determine whether the increased TDAG8 expression was due to an increased number of DRG neurons, we used in situ hybridization to examine L4-5 DRG 24 hours after CFA injection.
Spec (whether) Positive_regulation (increased) of Gene_expression (expression) of TDAG8 in neurons
14) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.36 Pain Relevance 0.39
Whether increased TDAG8 expression enhances TDAG8 function after inflammation has remained unclear.
Spec (Whether) Positive_regulation (increased) of Gene_expression (expression) of TDAG8 associated with inflammation
15) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.22 Pain Relevance 0.15
Increased TDAG8 expression in IB4-positive neurons after peripheral inflammation may increase the sensitivity of IB4-positive neurons to proton and capsaicin, through modulating the functions of ASICs or TRPV1.
Spec (may) Positive_regulation (increase) of Gene_expression (expression) of TDAG8 in IB4 associated with qutenza, inflammation and asic
16) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.56 Pain Relevance 1.02
To further determine whether the increased TDAG8 expression was due to an increased number of DRG neurons, we used in situ hybridization to examine L4-5 DRG 24 hours after CFA injection.
Positive_regulation (increased) of Gene_expression (expression) of TDAG8 in neurons
17) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.36 Pain Relevance 0.39
Increased mRNA levels were due to the increased number of neurons expressing TDAG8.
Positive_regulation (increased) of Gene_expression (expressing) of TDAG8 in neurons
18) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.84 Pain Relevance 0.81
We first examined proton signaling in HEK293T cells transfected with TDAG8.
Positive_regulation (transfected) of Gene_expression (transfected) of TDAG8
19) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.23 Pain Relevance 0.14
Given that the number of neurons expressing both TDAG8 and TRPV1 genes was increased as well and that TDAG8 activation sensitized TRPV1 responses to capsaicin, TDAG8 is likely involved in long-term chronic inflammatory pain by sensitizing TRPV1 function.
Positive_regulation (increased) of Gene_expression (expressing) of TDAG8 in neurons associated with qutenza and ipn
20) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.94 Pain Relevance 0.88

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