INT276868

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR, MTUS1) Golgi apparatus (MTOR, MTUS1) cytoplasm (MTOR, MTUS1)
nucleus (MTOR, MTUS1) endoplasmic reticulum (MTOR) microtubule organizing center (MTUS1)
Anatomy Link Frequency
muscle 2
MTOR (Homo sapiens)
MTUS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 50 95.70 Very High Very High Very High
Frailty 14 89.64 High High
Hypertrophy 1 89.16 High High
Stress 4 5.00 Very Low Very Low Very Low
Parkinson's Disease 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low
Hypokinesia 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the context of muscle atrophy, lower Akt activity decreases the activation of mammalian target of rapamycin (mTOR), leading to decreased protein synthesis and ribosomal biogenesis, as well as decreased mitochondrial biogenesis and function, as mTOR has been shown to regulate mitochondrial gene expression through the regulation of YY1/PGC-1?
mTOR Regulation (regulate) of Gene_expression (expression) of mitochondrial gene in muscle associated with muscular atrophy
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.33 Pain Relevance 0

General Comments

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