INT276874

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Context Info
Confidence 0.73
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.28
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppargc1a) RNA binding (Ppargc1a) mitochondrion organization (Ppargc1a)
nucleus (Ppargc1a) DNA binding (Ppargc1a) transcription factor binding (Ppargc1a)
Anatomy Link Frequency
muscle 1
skeletal muscle 1
Ppargc1a (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 246 95.24 Very High Very High Very High
cOX1 3 93.44 High High
Inflammation 3 58.96 Quite High
Acupuncture 30 51.52 Quite High
tolerance 27 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Fibrositis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 12 99.58 Very High Very High Very High
Insulin Resistance 85 99.56 Very High Very High Very High
Diabetes Mellitus 64 95.44 Very High Very High Very High
Sprains And Strains 7 94.64 High High
Stress 10 89.80 High High
Muscular Atrophy 50 83.88 Quite High
Weight Gain 4 75.36 Quite High
Metabolic Disorder 4 73.96 Quite High
Hypertrophy 1 67.68 Quite High
Frailty 14 66.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
protein content was not significantly altered by immobilization (not shown), PGC-1?
Localization (immobilization) of PGC
1) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.28 Pain Relevance 0
High-fat-diet-induced insulin resistance occurs together with decreased muscle PGC-1?
Localization (decreased) of PGC-1 in muscle associated with insulin resistance
2) Confidence 0.60 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.81 Pain Relevance 0.10
To support this, db/db mice that develop hyperglycemia have recorded lower skeletal muscle PGC-1?
Localization (skeletal muscle) of PGC-1 in skeletal muscle associated with hyperglycemia
3) Confidence 0.60 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.48 Pain Relevance 0.19
is a coactivator for NRF1 expression [24], discrepancy between induced PGC-1?
Localization (discrepancy) of PGC-1
4) Confidence 0.60 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.39 Pain Relevance 0.19
-oxidation genes is further potentiated by the nuclear hormone receptor coactivator PGC-1, a target of cyclic AMP (cAMP) response element binding (CREB), whose levels are increased during fasting and in diabetes [37, 38].
Localization (potentiated) of PGC-1 associated with diabetes mellitus
5) Confidence 0.22 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.32 Pain Relevance 0

General Comments

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