INT276878

Context Info Confidence 0.69 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 0.30 Pain Relevance 0

Anatomy Link Frequency muscle 3 skeletal muscle 2 FBXO32 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 12 5.00 Spinal cord 6 5.00 nalbuphine 4 5.00 analgesia 4 5.00 imagery 3 5.00 corticosteroid 1 5.00 anesthesia 1 5.00 lidocaine 1 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Muscular Atrophy 54 95.92 Frailty 14 69.20 Sepsis 12 39.36 Heart Rate Under Development 20 5.00 Myocardial Infarction 8 5.00 Coronary Heart Disease 4 5.00 Necrosis 4 5.00 Stress 4 5.00 Pressure Volume 2 Under Development 4 5.00 Cancer 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].

Transcription (levels) of MAFbx in skeletal muscle

1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].

Transcription (levels) of atrogin-1 in skeletal muscle

2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

However, when present in the nucleus, Foxo1, Foxo3 and Foxo4 can induce the transcription of the two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and MuRF1, which are thought responsible for the specific targeting of proteins for subsequent degradation by the proteasome [7], [8].

Transcription (transcription) of atrogin-1 in muscle

3) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

However, when present in the nucleus, Foxo1, Foxo3 and Foxo4 can induce the transcription of the two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and MuRF1, which are thought responsible for the specific targeting of proteins for subsequent degradation by the proteasome [7], [8].

Transcription (transcription) of MAFbx in muscle

4) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

Importantly, a recent study indicated that increases in the mRNA levels of atrogin-1 and MuRF-1 was not accompanied by increased protein levels of these genes during denervation-induced muscle atrophy in humans [28].

Transcription (levels) of atrogin-1 in muscle associated with muscular atrophy

5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.30 Pain Relevance 0

General Comments

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