INT276878

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 3
skeletal muscle 2
FBXO32 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 12 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
nalbuphine 4 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 54 95.92 Very High Very High Very High
Frailty 14 69.20 Quite High
Sepsis 12 39.36 Quite Low
Heart Rate Under Development 20 5.00 Very Low Very Low Very Low
Myocardial Infarction 8 5.00 Very Low Very Low Very Low
Coronary Heart Disease 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].
Transcription (levels) of MAFbx in skeletal muscle
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].
Transcription (levels) of atrogin-1 in skeletal muscle
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
However, when present in the nucleus, Foxo1, Foxo3 and Foxo4 can induce the transcription of the two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and MuRF1, which are thought responsible for the specific targeting of proteins for subsequent degradation by the proteasome [7], [8].
Transcription (transcription) of atrogin-1 in muscle
3) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
However, when present in the nucleus, Foxo1, Foxo3 and Foxo4 can induce the transcription of the two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and MuRF1, which are thought responsible for the specific targeting of proteins for subsequent degradation by the proteasome [7], [8].
Transcription (transcription) of MAFbx in muscle
4) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Importantly, a recent study indicated that increases in the mRNA levels of atrogin-1 and MuRF-1 was not accompanied by increased protein levels of these genes during denervation-induced muscle atrophy in humans [28].
Transcription (levels) of atrogin-1 in muscle associated with muscular atrophy
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.30 Pain Relevance 0

General Comments

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