INT276881

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.71
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 1
FBXO32 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 4 70.72 Quite High
Arthritis 1 64.24 Quite High
corticosteroid 1 59.36 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
nalbuphine 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 52 100.00 Very High Very High Very High
Coronary Heart Disease 2 98.72 Very High Very High Very High
Frailty 14 88.40 High High
Stress 4 86.36 High High
Heart Rate Under Development 10 75.12 Quite High
Hypokinesia 1 68.96 Quite High
Arthritis 1 64.24 Quite High
Aging 1 63.64 Quite High
Neuromuscular Disease 1 62.80 Quite High
Chronic Renal Failure 1 60.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, we observed no change in MAFbx/atrogin-1 and MuRF1 mRNA levels in myocardial tissue following LPS administration.
Neg (no) Regulation (change) of atrogin-1
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.17 Pain Relevance 0.04
Two novel Ub-protein ligases, atrogin-1 (muscle atrophy F-box protein) and muscle ring-finger protein (MuRF-1), are consistently up-regulated in murine models of muscle atrophy, and are thought to ubiquitinate both regulatory (e.g. calcineurin and MyoD) and structural (e.g. myosin and troponin I) proteins, thus directing the specific degradation of proteins during muscle atrophy [1], [12], [13], [15]–[21].
Regulation (regulated) of atrogin-1 in muscle associated with muscular atrophy
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 1.36 Pain Relevance 0.06
Secondly, we observed no change in MAFbx/atrogin-1 and MuRF1 mRNA levels in myocardial tissue following LPS administration.
Neg (no) Regulation (change) of MAFbx
3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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