INT276883

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 16
Disease Relevance 2.63
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skeletal muscle 4
myocardium 2
muscle 2
FBXO32 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 30 70.60 Quite High
Spinal cord 22 31.16 Quite Low
Arthritis 6 6.48 Low Low
imagery 18 5.00 Very Low Very Low Very Low
nalbuphine 10 5.00 Very Low Very Low Very Low
analgesia 10 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
lidocaine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 310 98.94 Very High Very High Very High
Sepsis 30 87.32 High High
Frailty 84 84.36 Quite High
Hypertrophy 6 80.00 Quite High
Myocardial Infarction 20 62.56 Quite High
Parkinson's Disease 18 46.92 Quite Low
Stress 24 28.60 Quite Low
Apoptosis 12 14.96 Low Low
Coronary Heart Disease 10 13.80 Low Low
Hypokinesia 6 11.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and IL-6 mRNA levels precedes increases in both MAFbx/atrogin-1 and MuRF1.
Positive_regulation (increases) of MAFbx
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.22 Pain Relevance 0.04
At the same time point, a significant increase in MAFbx/atrogin-1 and MuRF1 mRNA (3.7±0.7- and 19.5±1.9-fold increase vs. controls, respectively; P<0.05), in addition to protein levels of ?
Positive_regulation (increase) of MAFbx
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
and IL-6 mRNA levels precedes increases in both MAFbx/atrogin-1 and MuRF1.
Positive_regulation (increases) of atrogin-1
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.22 Pain Relevance 0.04
At the same time point, a significant increase in MAFbx/atrogin-1 and MuRF1 mRNA (3.7±0.7- and 19.5±1.9-fold increase vs. controls, respectively; P<0.05), in addition to protein levels of ?
Positive_regulation (increase) of atrogin-1
4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
We have recently shown the induction of lipopolysaccharide (LPS)-induced endotoxaemia in rodents to result in the reduction of total AKT protein levels, decreased cytosolic Foxo1 and Foxo3 phosphorylation, and increased levels of MAFbx/atrogin-1 protein and MuRF1 mRNA in fast-twitch skeletal muscle [3], where MAFbx/atrogin-1 and MuRF1 are considered important in the development of skeletal muscle proteolysis during catabolic events [4]–[6].
Positive_regulation (increased) of atrogin-1 in skeletal muscle
5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.16 Pain Relevance 0
It is feasible that this is in part a consequence of the failure of the myocardium to elicit events typically associated with UP-mediated protein degradation, most notably MAFbx/atrogin-1 and MuRF1 mRNA elevation.
Positive_regulation (elevation) of atrogin-1 in myocardium
6) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.05 Pain Relevance 0
We have recently shown the induction of lipopolysaccharide (LPS)-induced endotoxaemia in rodents to result in the reduction of total AKT protein levels, decreased cytosolic Foxo1 and Foxo3 phosphorylation, and increased levels of MAFbx/atrogin-1 protein and MuRF1 mRNA in fast-twitch skeletal muscle [3], where MAFbx/atrogin-1 and MuRF1 are considered important in the development of skeletal muscle proteolysis during catabolic events [4]–[6].
Positive_regulation (increased) of MAFbx in skeletal muscle
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.16 Pain Relevance 0
It is feasible that this is in part a consequence of the failure of the myocardium to elicit events typically associated with UP-mediated protein degradation, most notably MAFbx/atrogin-1 and MuRF1 mRNA elevation.
Positive_regulation (elevation) of MAFbx in myocardium
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.05 Pain Relevance 0
Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].
Positive_regulation (elevated) of atrogin-1 in skeletal muscle
9) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].
Positive_regulation (elevated) of MAFbx in skeletal muscle
10) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
In addition, lower Akt activity initiates signaling pathways that culminate in the induction of both atrogin-1 and MuRF-1 [14], [73], [74].
Positive_regulation (induction) of atrogin-1
11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.24 Pain Relevance 0
Figure 4A shows that the mRNA of both atrogin-1 and MuRF-1 increased (?
Positive_regulation (increased) of atrogin-1
12) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.09 Pain Relevance 0
In addition, the expression of atrogin-1 and MuRF-1 during muscle atrophy in humans is contentious, with some studies showing increased atrogin-1 and MuRF-1 mRNA, but not others [26], [28]–[31].
Positive_regulation (increased) of atrogin-1 in muscle associated with muscular atrophy
13) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.58 Pain Relevance 0
However, we were unable to detect atrogin-1 and MuRF protein using commercial antibodies (Abcam) and limited quantities of sample precluded direct measurements of Ub-proteasome activity.
Neg (unable) Positive_regulation (detect) of atrogin-1
14) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.22 Pain Relevance 0
Importantly, a recent study indicated that increases in the mRNA levels of atrogin-1 and MuRF-1 was not accompanied by increased protein levels of these genes during denervation-induced muscle atrophy in humans [28].
Positive_regulation (increases) of atrogin-1 in muscle associated with muscular atrophy
15) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.30 Pain Relevance 0
By contrast, atrogin-1 and MuRF-1 mRNAs were found to increase significantly at 48 H but not 14 D post-immobilization using qRT-PCR (Figure 4A).
Neg (not) Positive_regulation (increase) of atrogin-1
16) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.33 Pain Relevance 0

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